{"id":1894,"date":"2022-11-15T07:11:00","date_gmt":"2022-11-15T07:11:00","guid":{"rendered":"https:\/\/dianhuaminglu.com\/junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2\/"},"modified":"2023-05-04T10:31:51","modified_gmt":"2023-05-04T10:31:51","slug":"junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2","status":"publish","type":"post","link":"https:\/\/dianhuaminglu.com\/en\/junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2\/","title":{"rendered":"Junshi Biosciences Announces Submission of a Marketing Authorization Application to the European Medicines Agency for Toripalimab"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>The MAA was submitted in the EU for toripalimab seeking indications for the 1<sup>st<\/sup> line treatment of NPC and the 1<sup>st<\/sup> line treatment of ESCC<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>The global commercialization plan for toripalimab has expanded from China to the US and now, the EU<\/em><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>SHANGHAI, China, November 15, 2022 (GLOBE NEWSWIRE) \u2013 Shanghai Junshi Biosciences Co., Ltd (\u201cJunshi Biosciences\u201d, HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced today that the company has submitted a marketing authorization application (\u201cMAA\u201d) to the European Medicines Agency (\u201cEMA\u201d) for toripalimab. The indications requested in the MAA are:<\/p>\n\n\n\n<p>1. Toripalimab combined with cisplatin and gemcitabine for the first-line treatment of patients with locally recurrent or metastatic nasopharyngeal carcinoma (\u201cNPC\u201d);<\/p>\n\n\n\n<p>2. Toripalimab combined with paclitaxel and cisplatin for the first-line treatment of patients with unresectable locally advanced\/recurrent or metastatic esophageal squamous cell carcinoma (\u201cESCC\u201d)\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u201cFrom China to the US, and now the EU, the international commercialization of toripalimab is progressing steadily.\u201d said Dr. Patricia Keegan, Chief Medical Officer of Junshi\/TopAlliance Biosciences, \u201cThis was made possible by the substantial efficacy observed in NPC and ESCC as well as the excellent safety profile of toripalimab exhibited across various cancers; these results are particularly impactful when it comes to currently unmet medical needs. For instance, in a randomized, confirmatory clinical study, toripalimab is the first immune checkpoint inhibitor (\u201cICI\u201d) demonstrating a 13.2-month improvement in median progression-free survival and strong trend towards improved survival in patients with incurable NPC. Similarly, a randomized study has confirmed that toripalimab, in addition to taxane-based chemotherapy, significantly improves both survival and progression-free survival in patients with incurable ESCC. What is particularly notable is that efficacy was seen even patients with low PD-L1 tumor expression levels, for whom other ICI drugs do not appear efficacious. Going forward, we will continue to maintain close communication with the European regulatory agency and we look forward to making toripalimab available to patients in the EU as soon as possible.\u201d<\/p>\n\n\n\n<p>The MAA submission for NPC is based on the results from JUPITER-02 (an international randomized, placebo-controlled, double-blinded Phase III trial, NCT03581786) and POLARIS-02 (a multi-center, open label, pivotal Phase II clinical trial, NCT02915432). The JUPITER-02 results were first presented in June 2021 in a plenary session of the American Society of Clinical Oncology (\u201cASCO\u201d) annual meeting (#LBA2) and subsequently published in detail as the cover article of the September 2021 issue of <a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01444-0\"><em>Nature Medicine<\/em><\/a>. The POLARIS-02 results were published online in January 2021 in the <a href=\"https:\/\/ascopubs.org\/doi\/full\/10.1200\/JCO.20.02712\"><em>Journal of Clinical Oncology<\/em><\/a>.<\/p>\n\n\n\n<p>In 2021, two indications for the treatment of NPC were approved by the National Medical Products Administration (\u201cNMPA\u201d) based on the results of POLARIS-02 and JUPITER-02, thereby making toripalimab the world\u2019s first immune checkpoint inhibitor approved for the treatment of NPC. The FDA has accepted for review the resubmission of the Biologics License Application (\u201cBLA\u201d) for toripalimab for the treatment of NPC; the Prescription Drug User Fee Act (&#8220;PDUFA&#8221;) action date is set on December 23, 2022. If approved, toripalimab will be the first and only drug approved for the treatment of NPC in the U.S. In July 2022, toripalimab was designated as an orphan medicinal product by the European Commission (\u201cEC\u201d) for the treatment of NPC, and the designation will provide Junshi Biosciences with a number of incentives for research, development and marketing.<\/p>\n\n\n\n<p>The MAA submission for ESCC is based on the results from JUPITER-06 (a randomized, placebo-controlled, double-blinded, multi-center Phase III trial, NCT03829969). The study results were first presented in a mini-oral session during the European Society for Medical Oncology (\u201cESMO\u201d) Congress 2021, and later published in <a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(22)00059-9\"><em>Cancer Cell<\/em><\/a> with an editorial preview. In May 2022, the supplemental new drug application (\u201csNDA\u201d) for toripalimab in combination with paclitaxel and cisplatin for the first-line treatment of patients with unresectable locally advanced\/recurrent or distant metastatic ESCC was approved by the NMPA in China. Additionally, US FDA has also granted an orphan drug designation to toripalimab for the treatment of patients with ESCC.<\/p>\n\n\n\n\n\n<p><strong>About Nasopharyngeal Carcinoma<\/strong><\/p>\n\n\n\n<p>NPC is a malignant tumor that occurs in the nasopharyngeal mucosal epithelium and is one of the most common head and neck cancers in China. According to the World Health Organization, the number of newly diagnosed NPC cases in 2020 has exceeded 130,000 worldwide. Due to the location of the primary tumor, surgery is rarely an option, and patients with localized disease are treated primarily with chemotherapy and radiotherapy. In the United States and Europe, there are presently no drugs approved for the treatment of NPC, for which recommendations for initial treatment (gemcitabine and cisplatin) are based on randomized trials conducted in China.<\/p>\n\n\n\n<p><strong>About Esophageal Cancer<\/strong><\/p>\n\n\n\n<p>Esophageal cancer is one of the most common malignant tumors in alimentary tract. According to data released by GLOBOCAN 2020, 604,100 new esophageal cancer cases and 544,076 deaths due to esophageal cancer occurred globally. The incidence and death rates of esophageal cancer ranked seventh and sixth among all domestic malignant tumors respectively. ESCC and esophageal adenocarcinoma are the two main histological subtypes of esophageal cancer. For patients with advanced ESCC, recently updated ESMO guidelines recommend a platinum-fluoropyrimidine doublet with a PD-1 blocking antibody for treatment of locally advanced or metastatic ESCC. Of note, the indications for those PD-1 inhibitors approved in Europe are restricted to a subset of patients with ESCC. Therefore, there is an urgent unmet need for new drugs and treatments to extend the survival of patients with ESCC, particularly those with low PD-1 tumor expression.<\/p>\n\n\n\n<p><strong>About Toripalimab<\/strong><\/p>\n\n\n\n<p>Toripalimab is an anti-PD-1 monoclonal antibody developed for its ability to block PD-1 interactions with its ligands, PD-L1 and PD-L2, and for enhanced receptor internalization (endocytosis function). Blocking PD-1 interactions with PD-L1 and PD-L2 promotes the immune system\u2019s ability to attack and kill tumor cells.<\/p>\n\n\n\n<p>More than thirty company-sponsored toripalimab clinical studies covering more than fifteen indications have been conducted globally by Junshi Biosciences, including in China, the United States, Southeast Asia, and European countries. Ongoing or completed pivotal clinical trials evaluating the safety and efficacy of toripalimab cover a broad range of tumor types including cancers of the lung, nasopharynx, esophagus, stomach, bladder, breast, liver, kidney and skin.<\/p>\n\n\n\n<p>In China, toripalimab was the first domestic anti-PD-1 monoclonal antibody approved for marketing (approved in China as TUOYI\u00ae). Currently, there are six approved indications for toripalimab in China:<\/p>\n\n\n\n<ol class=\"wp-block-list\" type=\"1\">\n<li>unresectable or metastatic melanoma after failure of standard systemic therapy;<\/li>\n\n\n\n<li>recurrent or metastatic NPC after failure of at least two lines of prior systemic therapy;<\/li>\n\n\n\n<li>locally advanced or metastatic urothelial carcinoma that failed platinum-containing chemotherapy or progressed within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy;<\/li>\n\n\n\n<li>in combination with cisplatin and gemcitabine as the first-line treatment for patients with locally recurrent or metastatic NPC;<\/li>\n\n\n\n<li>in combination with paclitaxel and cisplatin in first-line treatment of patients with unresectable locally advanced\/recurrent or distant metastatic ESCC;<\/li>\n\n\n\n<li>in combination with pemetrexed and platinum as the first-line treatment in EGFR mutation-negative and ALK mutation-negative, unresectable, locally advanced or metastatic non-squamous non-small cell lung cancer (\u201cNSCLC\u201d).<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<p>The first three indications have been included in the National Reimbursement Drug List (\u201cNRDL\u201d) (2021 Edition). Toripalimab is the only anti-PD-1 monoclonal antibody included in the NRDL for melanoma and NPC.<\/p>\n\n\n\n<p>In the United States, the FDA is reviewing the BLA resubmission for toripalimab in combination with gemcitabine and cisplatin as first-line treatment for patients with advanced recurrent or metastatic NPC and for toripalimab monotherapy for the second-line or later treatment of recurrent or metastatic NPC after platinum-containing chemotherapy. The FDA has set a PDUFA action date for December 23, 2022. The FDA has granted Breakthrough Therapy designations for toripalimab in combination with chemotherapy for the first-line treatment of recurrent or metastatic NPC as well as for toripalimab monotherapy in the second or third-line treatment of recurrent or metastatic NPC. Additionally, the FDA has granted Fast Track designation for toripalimab for the treatment of mucosal melanoma and Orphan Drug designations for the treatment of esophageal cancer, NPC, mucosal melanoma, soft tissue sarcoma, and small cell lung cancer (&#8220;SCLC&#8221;).<\/p>\n\n\n\n<p>In the European Union, toripalimab was also designated as an orphan medicinal product by the European Commission for the treatment of NPC. In November 2022, a MAA was submitted to the EMA for: 1)toripalimab combined with cisplatin and gemcitabine for the first-line treatment of patients with locally recurrent or metastatic NPC and 2) toripalimab combined with paclitaxel and cisplatin for the first-line treatment of patients with unresectable locally advanced\/recurrent or metastatic ESCC.<\/p>\n\n\n\n<p><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>SHANGHAI, China, November 15, 2022 (GLOBE NEWSWIRE) \u2013 Shanghai Junshi Biosciences Co., Ltd (\u201cJunshi Biosciences\u201d, HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced today that the company has submitted a marketing authorization application (\u201cMAA\u201d) to the European Medicines Agency (\u201cEMA\u201d) for toripalimab. The indications requested in the MAA are:<\/p>\n","protected":false},"author":3,"featured_media":1117,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\n<title>Junshi Biosciences Announces Submission of a Marketing Authorization Application to the European Medicines Agency for Toripalimab - \u541b\u5b9e\u751f\u7269<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dianhuaminglu.com\/en\/junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Junshi Biosciences Announces Submission of a Marketing Authorization Application to the European Medicines Agency for Toripalimab - \u541b\u5b9e\u751f\u7269\" \/>\n<meta property=\"og:description\" content=\"SHANGHAI, China, November 15, 2022 (GLOBE NEWSWIRE) \u2013 Shanghai Junshi Biosciences Co., Ltd (\u201cJunshi Biosciences\u201d, HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced today that the company has submitted a marketing authorization application (\u201cMAA\u201d) to the European Medicines Agency (\u201cEMA\u201d) for toripalimab. 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