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5\u5929\uff09\u3002<\/p>\n\n\n\n<p>VV116\u7ec4\u548cPAXLOVID\u7ec4\u5728\u201c\u81f3\u6301\u7eed\u75c7\u72b6\u6d88\u5931\u7684\u65f6\u95f4\u201d\u3001\u201c\u81f3\u9996\u6b21SARS-CoV-2\u6838\u9178\u9634\u6027\u65f6\u95f4\u201d\u65b9\u9762\u8868\u73b0\u7c7b\u4f3c\uff0c\u4e2d\u4f4d\u65f6\u95f4\u5747\u4e3a7\u5929\u3002\u5728\u6bcf\u4e00\u4e2a\u9884\u8bbe\u65f6\u95f4\u70b9\uff08\u7b2c5\u30017\u300110\u300114\u300128\u5929\uff09\uff0cVV116\u7ec4\u75c7\u72b6\u7f13\u89e3\u7684\u60a3\u8005\u6bd4\u4f8b\u5747\u9ad8\u4e8ePAXLOVID\u7ec4\u3002\u4e24\u7ec4\u60a3\u8005\u5747\u672a\u53d1\u751f\u8fdb\u5c55\u4e3a\u91cd\u5ea6\/\u5371\u91cdCOVID-19\u6216\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u672c\u7814\u7a76\u4e2d\u7ea63\/4\u7684\u60a3\u8005\u66fe\u63a5\u79cd\u8fc7\u65b0\u51a0\u75ab\u82d7\uff0c\u800c\u6b64\u7c7b\u60a3\u8005\u5728\u5927\u591a\u6570\u7684\u7814\u7a76\u4e2d\u4f1a\u88ab\u6392\u9664\u5728\u5916\uff0c\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cVV116\u548cPAXLOVID\u5728\u63a5\u79cd\u6216\u672a\u63a5\u79cd\u75ab\u82d7\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7597\u7ed3\u679c\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002<\/p>\n\n\n\n<p>\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cVV116\u6bd4PAXLOVID\u7684\u5b89\u5168\u6027\u987e\u8651\u66f4\u5c11\u3002VV116\u7ec4\u7684AE\u53d1\u751f\u7387\u4f4e\u4e8ePAXLOVID\u7ec4\uff08\u6240\u6709\u7ea7\u522b\u7684AE\uff1a67.4% vs. 77.3%\uff0c3\u62164\u7ea7AE\uff1a2.6% vs. 5.7%\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cPAXLOVID\u4e0e\u591a\u79cd\u836f\u7269\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff08Drug-drug interaction\uff09\uff0c\u800cVV116\u4e0d\u4f1a\u6291\u5236\u6216\u8bf1\u5bfc\u4e3b\u8981\u836f\u7269\u4ee3\u8c22\u9176\uff0c\u6216\u8005\u6291\u5236\u4e3b\u8981\u836f\u7269\u8f6c\u8fd0\u86cb\u767d\uff0c\u56e0\u6b64\u4e0e\u5408\u5e76\u7528\u836f\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u6027\u5c0f\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>1. Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<br>2. Qian, Hj., et al. Acta Pharmacol Sin (2022).<br>3. Shen Y, et al. Emerg Microbes Infect 2022;11:1518-23.<br>4. \u6b64\u6b21\u53c2\u4e0e\u7814\u7a76\u76847\u5bb6\u65b0\u51a0\u80ba\u708e\u5b9a\u70b9\u533b\u9662\u5206\u522b\u4e3a\uff1a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4ec1\u6d4e\u533b\u9662\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u6d66\u4e1c\u533b\u9662\u3001\u4e0a\u6d77\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u3001\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u66d9\u5149\u533b\u9662\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u540c\u4ec1\u533b\u9662<\/strong><\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u5173\u4e8eVV116\uff08JT001\uff09<\/strong><\/p>\n\n\n\n<p>VV116\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u7c7b\u836f\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u590d\u5236\u3002\u4e34\u5e8a\u524d\u836f\u6548\u5b66\u7814\u7a76\u663e\u793a\uff0cVV116\u5728\u4f53\u5916\u5bf9\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u5df2\u77e5\u7a81\u53d8\u682a\u90fd\u8868\u73b0\u51fa\u663e\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff1b\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u4f4e\u5242\u91cf\u7684VV116\u5c31\u53ef\u5c06\u80ba\u90e8\u75c5\u6bd2\u6ef4\u5ea6\u964d\u4f4e\u81f3\u68c0\u6d4b\u9650\u4ee5\u4e0b\uff0c\u53ef\u663e\u8457\u6539\u5584\u80ba\u7ec4\u7ec7\u75c5\u7406\u53d8\u5316\uff0c\u8868\u73b0\u51fa\u8f83\u5f3a\u7684\u6297\u75c5\u6bd2\u529f\u6548\u3002\u4e34\u5e8a\u524d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cVV116\u5177\u6709\u5f88\u9ad8\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u53e3\u670d\u5438\u6536\u540e\uff0c\u8fc5\u901f\u4ee3\u8c22\u4e3a\u6bcd\u4f53\u6838\u82f7\uff0c\u5e76\u5728\u4f53\u5185\u7ec4\u7ec7\u5e7f\u6cdb\u5206\u5e03\u3002<\/p>\n\n\n\n<p>VV116\u7531\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u65b0\u7586\u7406\u5316\u6280\u672f\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e2d\u4e9a\u836f\u7269\u7814\u53d1\u4e2d\u5fc3\/\u4e2d\u4e4c\u533b\u836f\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e26\u4e00\u8def\u201d\u8054\u5408\u5b9e\u9a8c\u5ba4\uff09\u3001\u4e34\u6e2f\u5b9e\u9a8c\u5ba4\u3001\u82cf\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u65fa\u5c71\u65fa\u6c34\uff09\u548c\u541b\u5b9e\u751f\u7269\u5171\u540c\u7814\u53d1\u3002\u541b\u5b9e\u751f\u7269\u4e0e\u65fa\u5c71\u65fa\u6c34\u5171\u540c\u627f\u62c5\u8be5\u836f\u7269\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u5de5\u4f5c\uff0c\u5408\u4f5c\u533a\u57df\u4e3a\u9664\u4e2d\u4e9a\u4e94\u56fd\u3001\u4fc4\u7f57\u65af\u3001\u5317\u975e\u3001\u4e2d\u4e1c\u56db\u4e2a\u533a\u57df\u5916\u7684\u5168\u7403\u8303\u56f4\u3002<\/p>\n\n\n\n<p>\u541b\u5b9e\u751f\u7269\u4e0e\u65fa\u5c71\u65fa\u6c34\u5df2\u5728\u4e2d\u56fd\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u5b8c\u6210\u4e863\u9879I\u671f\u7814\u7a76<sup>[1]<\/sup>\uff0c\u5e76\u5728\u4e2d\u56fd\u8f7b\/\u4e2d\u5ea6COVID-19\u9ad8\u98ce\u9669\u60a3\u8005\u4e2d\u5b8c\u62101\u9879III\u671f\u7814\u7a76<sup>[2]<\/sup>\uff08NCT05341609\uff09\uff0c\u7814\u7a76\u7ed3\u679c\u5206\u522b\u53d1\u8868\u4e8eActa Pharmacologica Sinica\u548c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08<em>The New England Journal of Medicine<\/em>\uff09\u3002<\/p>\n\n\n\n<p>2021\u5e74\uff0cVV116\u5728\u4e4c\u5179\u522b\u514b\u65af\u5766\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">[1] Qian, Hj., et al. Acta Pharmacol Sin (2022).<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">[2] Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac\u65f6\u95f42022\u5e7412\u670829\u65e5\uff0c\u5168\u7403\u6743\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08The New England Journal of Medicine\uff0cNEJM\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a176.079\uff09\u5728\u7ebf\u53d1\u8868\u4e86\u541b\u5b9e\u751f\u7269\u65d7\u4e0b\u7684\u53e3\u670d\u6838\u82f7\u7c7b\u6297\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u836f\u7269VV116\uff08JT001\uff09\u5bf9\u6bd4\u5948\u739b\u7279\u97e6\u7247\/\u5229\u6258\u90a3\u97e6\u7247\u7ec4\u5408\u836f\u7269\uff08PAXLOVID\uff09\u7528\u4e8e\u4f34\u6709\u8fdb\u5c55\u4e3a\u91cd\u5ea6\u5305\u62ec\u6b7b\u4ea1\u9ad8\u98ce\u9669\u56e0\u7d20\u7684\u8f7b\u81f3\u4e2d\u5ea6\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff08COVID-19\uff09\u60a3\u8005\u65e9\u671f\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT05341609\uff09\u6210\u679c 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