{"id":1485,"date":"2022-05-16T06:30:28","date_gmt":"2022-05-16T06:30:28","guid":{"rendered":"https:\/\/dianhuaminglu.com\/?p=1485"},"modified":"2023-01-10T07:12:28","modified_gmt":"2023-01-10T07:12:28","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e9%a3%9f%e7%ae%a1%e9%b3%9e%e7%99%8c","status":"publish","type":"post","link":"https:\/\/dianhuaminglu.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e9%a3%9f%e7%ae%a1%e9%b3%9e%e7%99%8c\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u98df\u7ba1\u9cde\u764c\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6"},"content":{"rendered":"\n<p><a>2022<\/a>\u5e745\u670816\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8fdc\u5904\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b0\u9002\u5e94\u75c7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002\u8fd9\u662f\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u7b2c\u4e94\u9879\u9002\u5e94\u75c7\uff0c\u5c06\u4e3a\u4e2d\u56fd\u665a\u671f\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9886\u57df\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u7edf\u8ba1\uff0c2020\u5e74\u4e2d\u56fd\u7684\u98df\u7ba1\u764c\u65b0\u53d1\u75c5\u4f8b\u6570\u9ad8\u8fbe32\u4e07\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u8fbe\u523030\u4e07\uff0c\u5747\u5360\u5230\u5168\u7403\u7684\u4e00\u534a\u4ee5\u4e0a\uff0c\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5206\u522b\u4f4d\u5c45\u56fd\u5185\u6240\u6709\u6076\u6027\u80bf\u7624\u4e2d\u7684\u7b2c\u4e94\u548c\u7b2c\u56db\u4f4d<a id=\"_ftnref1\" href=\"#_ftn1\"><sup>[1]<\/sup><\/a><a id=\"_ftnref2\" href=\"#_ftn2\"><sup>[2]<\/sup><\/a>\u3002\u98df\u7ba1\u9cde\u764c\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u4e24\u79cd\u4e3b\u8981\u7ec4\u7ec7\u5b66\u4e9a\u578b\uff0c\u4e2d\u56fd\u60a3\u8005\u4ee5\u98df\u7ba1\u9cde\u764c\u4e3a\u4e3b\u8981\u4e9a\u578b\uff0c\u7ea6\u5360\u603b\u4f53\u53d1\u75c5\u7387\u768490%<a id=\"_ftnref3\" href=\"#_ftn3\"><sup>[3]<\/sup><\/a>\u3002\u5bf9\u4e8e\u665a\u671f\u98df\u7ba1\u9cde\u764c\u60a3\u8005\uff0c\u5f53\u524d\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u591a\u91c7\u7528\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\uff0c\u4f46\u4e34\u5e8a\u83b7\u76ca\u6709\u9650\uff0c5\u5e74\u603b\u751f\u5b58\u7387\u4e0d\u8db320%\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6848\u6765\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u671f<a id=\"_ftnref4\" href=\"#_ftn4\"><sup>[4]<\/sup><\/a>\u3002<\/p>\n\n\n\n<p>\u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u7684\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8cJUPITER-06\uff08NCT03829969\uff09\u7684\u7814\u7a76\u6570\u636e\u3002\u8be5\u7814\u7a76\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408TP\u5316\u7597\uff08\u7d2b\u6749\u9187+\u987a\u94c2\uff09\u4e0e\u5b89\u6170\u5242\u8054\u5408TP\u5316\u7597\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff1b\u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u9605\u7247[BICR]\uff0c\u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6[RECIST]1.1\u8bc4\u4f30\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u7b49\uff0c\u5171\u6709514\u4f8b\u60a3\u8005\u5165\u7ec4\u8bd5\u9a8c\uff0c\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u6cbb\u7597\u7ec4\uff08\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408TP\u5316\u7597\uff09\u6216\u5b89\u6170\u5242\u7ec4\uff08\u5b89\u6170\u5242\u8054\u5408TP\u5316\u7597\uff09\u3002<\/p>\n\n\n\n<p>JUPITER-06\u7684\u7814\u7a76\u6210\u679c\u83b7\u5f97\u56fd\u9645\u9876\u5c16\u80bf\u7624\u5b66\u6742\u5fd7\u300aCancer Cell\u300b\uff08\u5f71\u54cd\u56e0\u5b50\uff1a31.743\uff09\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408TP\u5316\u7597\u8ba9\u66f4\u591a\u665a\u671f\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u83b7\u5f97\u4e86\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u5176\u4e2d\u4e2d\u4f4dOS\u5927\u5e45\u5ef6\u957f\u81f317\u4e2a\u6708\uff0cPFS\u4e3a5.7\u4e2a\u6708\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e42%\uff08HR=0.58\uff0cP\uff1c0.0001\uff09\uff0c\u4e14\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u5982\u4f55\uff0c\u5747\u53ef\u83b7\u76ca<strong>\u3002<\/strong>\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u5728\u5316\u7597\u57fa\u7840\u4e0a\u52a0\u5165\u7279\u745e\u666e\u5229\u5355\u6297\u8fdb\u884c\u6cbb\u7597\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p><strong>JUPITER-06<\/strong><strong>\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u4e2d\u56fd\u662f\u98df\u7ba1\u764c\u7684\u9ad8\u53d1\u56fd\u5bb6\u4e4b\u4e00\uff0c\u4f46\u7531\u4e8e\u4e1c\u897f\u65b9\u60a3\u8005\u7684\u53d1\u75c5\u539f\u56e0\u548c\u75c5\u7406\u7279\u70b9\u4e0d\u540c\uff0c\u9488\u5bf9\u6211\u56fd\u4e3b\u8981\u4e9a\u578b\u98df\u7ba1\u9cde\u764c\u5f00\u53d1\u7684\u521b\u65b0\u7597\u6cd5\u7684\u4e34\u5e8a\u8bc1\u636e\u76f8\u5bf9\u7f3a\u4e4f\u3002JUPITER-06\u5e94\u7528\u4e86\u6211\u56fd\u539f\u7814\u7684PD-1\u6291\u5236\u5242\u8054\u5408\u66f4\u8d34\u5408\u672c\u571f\u4e34\u5e8a\u5b9e\u8df5\u7684TP\u5316\u7597\u65b9\u6848\uff0c\u7814\u7a76\u7ed3\u679c\u8ba9\u6211\u4eec\u975e\u5e38\u60ca\u559c\uff0c\u60a3\u8005\u7684PFS\u548cOS\u5747\u5f97\u5230\u663e\u8457\u6539\u5584\uff0c\u5237\u65b0\u4e86\u665a\u671f\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u751f\u5b58\u671f\u7eaa\u5f55\u3002\u8fd9\u662f\u2018\u4e2d\u56fd\u65b9\u6848\u2019\u5bf9\u56fd\u9645\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u91cd\u5927\u8d21\u732e\u3002\u201d<\/p>\n\n\n\n<p>\u5728\u6d77\u5916\u5e02\u573a\u65b9\u9762\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u98df\u7ba1\u764c\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff08Orphan-drug Designation\uff09\uff0c\u6709\u52a9\u4e8e\u52a0\u5feb\u63a8\u8fdb\u8be5\u836f\u7269\u5728\u7f8e\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u4e0a\u5e02\u6ce8\u518c\u7684\u8fdb\u5ea6\u3002\u541b\u5b9e\u751f\u7269\u8ba1\u5212\u4e0e\u6d77\u5916\u5408\u4f5c\u4f19\u4f34Coherus\u5728\u4eca\u5e74\u5c31\u63d0\u4ea4\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\u9002\u5e94\u75c7\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u4e0e\u7f8e\u56fdFDA\u8fdb\u884c\u6c9f\u901a\u4ea4\u6d41\u3002<\/p>\n\n\n\n<p><strong>\u201c<\/strong>\u98df\u7ba1\u764c\u8d77\u75c5\u9690\u533f\uff0c\u8bb8\u591a\u60a3\u8005\u521d\u8bca\u65f6\u5df2\u662f\u665a\u671f\uff0c\u7136\u800c\u5316\u7597\u4f5c\u4e3a\u665a\u671f\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u9884\u540e\u8f83\u5dee\uff0c\u6211\u4eec\u5e0c\u671b\u4e3a\u8fd9\u90e8\u5206\u60a3\u8005\u63d0\u4f9b\u6548\u679c\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u201d<strong>\u541b\u5b9e\u751f\u7269\u5168\u7403\u7814\u53d1\u603b\u88c1\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff0c\u201c\u541b\u5b9e\u751f\u7269\u6301\u7eed\u5173\u6ce8\u672c\u571f\u9ad8\u53d1\uff0c\u4e14\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u8f83\u597d\u54cd\u5e94\u3001\u4e34\u5e8a\u6025\u9700\u6cbb\u7597\u7684\u7624\u79cd\u3002\u901a\u8fc7\u6211\u4eec\u4e0eJUPITER-06\u7684\u7814\u7a76\u8005\u3001\u60a3\u8005\u7b49\u591a\u65b9\u9762\u7684\u5171\u540c\u52aa\u529b\uff0c\u7814\u7a76\u8bc1\u5b9e\u5728\u5316\u7597\u57fa\u7840\u4e0a\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u8868\u73b0\u51fa\u4e86\u660e\u663e\u7684\u7597\u6548\u63d0\u5347\u3002\u6211\u4eec\u4e5f\u5c06\u79ef\u6781\u4e0e\u6d77\u5916\u76d1\u7ba1\u673a\u6784\u6c9f\u901a\uff0c\u4ee5\u671f\u8ba9\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u533b\u5b66\u5b98Patricia Keegan\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u7279\u745e\u666e\u5229\u5355\u6297\u80fd\u591f\u5728\u665a\u671f\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u9886\u57df\u83b7\u6279\u65b0\u9002\u5e94\u75c7\uff0c\u4e3a\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u5e26\u6765\u6211\u4eec\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\uff0c\u5176\u4e2d\u4e5f\u5305\u62ec\u8fc7\u5f80\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6548\u6709\u9650\u7684PD-L1\u4f4e\u8868\u8fbe\u80bf\u7624\u60a3\u8005\u3002\u541b\u5b9e\u751f\u7269\u5c06\u59cb\u7ec8\u9075\u5faa\u2018\u7acb\u8db3\u4e2d\u56fd\u3001\u5e03\u5c40\u5168\u7403\u2019\u6218\u7565\uff0c\u7ee7\u7eed\u805a\u7126\u672a\u88ab\u6ee1\u8db3\u7684\u80bf\u7624\u9886\u57df\uff0c\u4e0d\u65ad\u63a2\u7d22\u65b0\u7684\u514d\u75ab\u836f\u7269\u6cbb\u7597\u65b9\u5411\uff01\u201d<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a id=\"_ftn1\" href=\"#_ftnref1\">[1]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a href=\"#_ftnref2\" id=\"_ftn2\">[2]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a href=\"#_ftnref3\" id=\"_ftn3\">[3]<\/a> Abnet, C.C., Arnold, M., and Wei, W.Q. (2018). Epidemiology of Esophageal Squamous Cell Carcinoma. Gastroenterology 154, 360-373.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><a id=\"_ftn4\" href=\"#_ftnref4\">[4]<\/a> Wang et al., Toripalimab plus chemotherapy in treatment-naive, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial, Cancer Cell. 2022.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. 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