{"id":1654,"date":"2022-01-10T08:35:31","date_gmt":"2022-01-10T08:35:31","guid":{"rendered":"https:\/\/dianhuaminglu.com\/?p=1654"},"modified":"2023-01-10T08:37:39","modified_gmt":"2023-01-10T08:37:39","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e4%b8%8ecoherus%e6%89%a9%e5%a4%a7%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e9%a2%86%e5%9f%9f%e5%90%88%e4%bd%9c%ef%bc%8c%e5%b0%86%e5%9c%a8%e7%be%8e%e5%8a%a0%e5%85%b1","status":"publish","type":"post","link":"https:\/\/dianhuaminglu.com\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e4%b8%8ecoherus%e6%89%a9%e5%a4%a7%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e9%a2%86%e5%9f%9f%e5%90%88%e4%bd%9c%ef%bc%8c%e5%b0%86%e5%9c%a8%e7%be%8e%e5%8a%a0%e5%85%b1\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u4e0eCoherus\u6269\u5927\u80bf\u7624\u514d\u75ab\u9886\u57df\u5408\u4f5c\uff0c\u5c06\u5728\u7f8e\u52a0\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316JS006\uff08\u6297TIGIT\u5355\u6297\uff09"},"content":{"rendered":"\n
\u5317\u4eac\u65f6\u95f42022\u5e741\u670810\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u4e0eCoherus BioSciences\uff08NASDAQ\uff1aCHRS\uff09\u5171\u540c\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c06\u6269\u5927\u4e8e2021\u5e74\u8fbe\u6210\u7684\u80bf\u7624\u514d\u75ab\u9886\u57df\u5408\u4f5c\uff0cCoherus\u5df2\u542f\u52a8\u884c\u4f7fJS006\uff08\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u6297TIGIT\u5355\u6297\uff09\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u7684\u8bb8\u53ef\u9009\u62e9\u6743\u7684\u7a0b\u5e8f\u3002\u5728\u9075\u5b88\u9002\u7528\u6cd5\u5f8b\u53ca\u6ee1\u8db3\u53cc\u65b9\u4e66\u9762\u7ea6\u5b9a\u7684\u6761\u4ef6\u7684\u524d\u63d0\u4e0b\uff0cCoherus\u5c06\u5411\u541b\u5b9e\u751f\u7269\u652f\u4ed83500\u4e07\u7f8e\u5143\u9996\u4ed8\u6b3e\uff0c\u6700\u9ad8\u8fbe2.55\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u3001\u7533\u62a5\u548c\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u4ea7\u54c1\u9500\u552e\u51c0\u989d18%\u7684\u9500\u552e\u5206\u6210\u3002\u9884\u8ba1\u4ea4\u6613\u5c06\u5728\u9002\u7528\u6cd5\u5f8b\u8981\u6c42\u7684\u653f\u5e9c\u624b\u7eed\u5b8c\u6bd5\u540e\u5b8c\u6210\u3002<\/p>\n\n\n\n
TIGIT\uff08T cell immunoglobulin and ITIM domain\uff0cT\u7ec6\u80de\u514d\u75ab\u7403\u86cb\u767d\u542b\u80de\u5185ITIM\u7ed3\u6784\u57df\uff09\u963b\u65ad\u6297\u4f53\u4e0ePD-1\/PD-L1\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u663e\u793a\u51fa\u534f\u540c\u7684\u6297\u80bf\u7624\u6d3b\u6027\u6f5c\u529b\u3002\u6839\u636e\u591a\u9879\u4e34\u5e8a\u524d\u7814\u7a76\uff0cJS006\u663e\u793a\u51fa\u4f18\u5f02\u7684\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u4ee5\u53ca\u5bf9TIGIT\u901a\u8def\u7684\u5f3a\u6291\u5236\u4f5c\u7528\u3002\u76ee\u524d\uff0cJS006\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u5206\u522b\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u6279\u51c6\u3002\u4e00\u9879\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u62d3\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\uff08NCT05061628\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u65e8\u5728\u8bc4\u4f30JS006\u5355\u836f\u53ca\u8054\u5408\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\u3002<\/p>\n\n\n\n
\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u4e0eCoherus\u8fdb\u4e00\u6b65\u62d3\u5c55\u53cc\u65b9\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u5353\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u5728\u5148\u524d\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u53d6\u5f97\u591a\u9879\u9636\u6bb5\u6027\u6210\u679c\u7684\u57fa\u7840\u4e0a\uff0c\u53c8\u5c06\u65b0\u7eb3\u5165\u6297TIGIT\u5355\u6297\u836f\u7269JS006\uff0c\u201d\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u6267\u884c\u5b98\u674e\u5b81\u535a\u58eb\u8868\u793a\u3002\u201c\u9075\u5faa\u516c\u53f8\u2018\u7acb\u8db3\u4e2d\u56fd\uff0c\u5e03\u5c40\u5168\u7403\u2019\u7684\u56fd\u9645\u5316\u6218\u7565\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u4e1c\u5357\u4e9a\u3001\u6b27\u6d32\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u4e86\u591a\u9879\u8de8\u56fd\u7814\u53d1\u9879\u76ee\uff0c\u8fd9\u5f52\u529f\u4e8e\u541b\u5b9e\u751f\u7269\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u7814\u53d1\u4e2d\u5fc3\u7684\u4e34\u5e8a\u524d\u4e0e\u4e34\u5e8a\u56e2\u961f\u7684\u7d27\u5bc6\u534f\u4f5c\u3002\u76f8\u4fe1\u4e0eCoherus\u7684\u5408\u4f5c\u5c06\u8fdb\u4e00\u6b65\u5f3a\u5316\u6211\u4eec\u7684\u4ea7\u54c1\u5728\u7f8e\u52a0\u5730\u533a\u7684\u7814\u53d1\u548c\u5546\u4e1a\u5316\u3002\u201d<\/p>\n\n\n\n
\u541b\u5b9e\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u59da\u76db\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u81ea2012\u5e74\u8d77\uff0c\u541b\u5b9e\u751f\u7269\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u5df2\u642d\u5efa\u8d77\u4e30\u5bcc\u3001\u4e92\u8865\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u671f\u901a\u8fc7I-O\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\uff0c\u6216\u514d\u75ab\u7597\u6cd5\u4e0e\u4f20\u7edf\u653e\u5316\u7597\u3001\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u3001\u7ec6\u80de\u56e0\u5b50\u7c7b\u836f\u7269\u7b49\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u6cbb\u7597\u63a2\u7d22\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u6548\u679c\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002\u5176\u4e2d\uff0c\u6297TIGIT\u5355\u6297\u4e0e\u6297PD-1\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u9887\u5177\u524d\u666f\uff0c\u6709\u671b\u589e\u52a0\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7b54\uff0c\u6269\u5927\u53d7\u76ca\u4eba\u7fa4\u7684\u8303\u56f4\u3002\u6211\u4eec\u671f\u5f85\u4e0eCoherus\u5f00\u5c55\u6df1\u5316\u5408\u4f5c\uff0c\u5c3d\u5feb\u5728\u4e0d\u540c\u7624\u79cd\u4e2d\u63a8\u8fdbJS006\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u8054\u5408\u7597\u6cd5\u5f00\u53d1\u3002\u201d<\/p>\n\n\n\n \u201cTIGIT\u4f5c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u524d\u6cbf\u9776\u70b9\uff0c\u5df2\u5728\u591a\u4e2a\u4e3b\u8981\u80bf\u7624\u7c7b\u578b\u4e2d\u663e\u793a\u51fa\u6cbb\u7597\u6f5c\u529b\u3002\u884c\u4f7fJS006\u7684\u9009\u62e9\u6743\u6807\u5fd7\u7740Coherus\u4f5c\u4e3a\u80bf\u7624\u514d\u75ab\u5f00\u53d1\u4f01\u4e1a\u7684\u5f00\u7aef\uff0c\u6253\u9020\u4e30\u5bcc\u7684\u4e34\u5e8a\u4e0e\u4e34\u5e8a\u524d\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u9a71\u52a8\u6211\u4eec\u7684\u957f\u671f\u53d1\u5c55\uff0c\u201dCoherus\u9996\u5e2d\u6267\u884c\u5b98Denny Lanfear<\/strong>\u8868\u793a\u3002\u201c\u6211\u4eec\u5e0c\u671b\u6210\u4e3a\u4e00\u5bb6\u9886\u5148\u7684\u80bf\u7624\u514d\u75ab\u4f01\u4e1a\uff0c\u6b63\u5411\u7740\u8fd9\u4e00\u76ee\u6807\u5feb\u901f\u8fdb\u6b65\u3002\u901a\u8fc7\u7279\u745e\u666e\u5229\u5355\u6297\u4e0e\u5176\u4ed6\u65b0\u9776\u70b9\u7597\u6cd5\uff0c\u5982TIGIT\u6291\u5236\u5242\u7684\u8054\u5408\u7597\u6cd5\u5f00\u53d1\uff0c\u5c06\u8ba9\u6211\u4eec\u8fdb\u5165\u672a\u6765\u4e0d\u65ad\u589e\u957f\u7684\u5e02\u573a\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u4e0eJS006\u662f\u6211\u4eec\u7ba1\u7ebf\u4e2d\u9996\u4e2a\u65b0\u836f\u8054\u5408\u7597\u6cd5\uff0c\u6211\u4eec\u5df2\u5e94\u7528Coherus\u64c5\u957f\u7684\u5206\u6790\u3001\u86cb\u767d\u79d1\u5b66\u548c\u751f\u7269\u4fe1\u606f\u5b66\u80fd\u529b\u5f00\u53d1\u5176\u4ed6\u53ef\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8fdb\u884c\u8054\u7528\u7684\u5019\u9009\u836f\u7269\u3002\u9996\u6b3e\u521b\u65b0\u4ea7\u54c1\u9884\u8ba1\u5c06\u4e8e2023\u5e74\u8fdb\u5165\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002\u201d<\/p>\n\n\n\n \u201c\u963b\u65adTIGIT\u901a\u8def\u53ef\u80fd\u662f\u514b\u670d\u68c0\u67e5\u70b9\u6291\u5236\u8010\u836f\u7684\u5173\u952e\u6f5c\u5728\u673a\u5236\u3002\u6211\u4eec\u76f8\u4fe1TIGIT\u4e0ePD-1\u7684\u53cc\u91cd\u514d\u75ab\u7597\u6cd5\u53ef\u589e\u5f3aPD-1\u836f\u7269\u7684\u7597\u6548\uff0c\u5e76\u4e3a\u591a\u4e2a\u7624\u79cd\u6811\u7acb\u65b0\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u201dCoherus\u9996\u5e2d\u5f00\u53d1\u5b98Theresa LaVallee\u535a\u58eb\u8868\u793a\u3002\u201c\u8fd1\u671f\u53d1\u8868\u8868\u660e\uff0c\u6211\u4eec\u7684PD-1\u6291\u5236\u5242\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u5ef6\u957f\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u541b\u5b9e\u751f\u7269\u5408\u4f5c\uff0c\u5728\u6b64\u7597\u6548\u4fe1\u53f7\u7684\u57fa\u7840\u4e0a\u518d\u63a5\u518d\u5389\uff0c\u8bc4\u4f30JS006\u548c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u6f5c\u529b\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u3001\u66f4\u6709\u6548\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002\u201d<\/p>\n\n\n\n <\/p>\n\n\n\n\n\n \u5173\u4e8eJS006<\/strong><\/p>\n\n\n\n JS006\u662f\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u7279\u5f02\u6027\u6297\u4ebaTIGIT\u7684\u91cd\u7ec4\u4eba\u6e90\u5316IgG4\u03ba\u5355\u514b\u9686\u6297\u4f53\u3002\u5305\u62ec\u5907\u7528\u5019\u9009\u7269\u5728\u5185\uff0cJS006\u9879\u76ee\u5305\u62ec\u591a\u4e2a\u5177\u6709\u6c89\u9ed8\u548c\u6d3b\u6027Fc\u529f\u80fd\u7684\u5206\u5b50\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cJS006\u53ef\u7279\u5f02\u6027\u963b\u65adTIGIT-PVR\u6291\u5236\u901a\u8def\u3002TIGIT\u5728T\u7ec6\u80de\u548cNK\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u53ef\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0a\u9ad8\u8868\u8fbe\u7684PVR\u53d7\u4f53\u76f8\u4e92\u7ed3\u5408\uff0c\u4ecb\u5bfc\u514d\u75ab\u53cd\u5e94\u7684\u6291\u5236\u4fe1\u53f7\uff0c\u4ece\u800c\u76f4\u63a5\u6291\u5236T\u7ec6\u80de\u548cNK\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002\u5927\u91cf\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0cTIGIT\u901a\u8def\u7684\u6fc0\u6d3b\u53ef\u80fd\u662fPD-1\u6291\u5236\u5242\u8010\u836f\u7684\u5173\u952e\u6f5c\u5728\u673a\u5236\u3002TIGIT\u548cPD-1\/PD-L1\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u4e5f\u663e\u793a\u51fa\u534f\u540c\u589e\u5f3a\u6297\u80bf\u7624\u53cd\u5e94\u7684\u6f5c\u529b\uff0c\u4ee5\u514b\u670dPD-1\u6291\u5236\u5242\u8010\u836f\u6027\u5e76\u6269\u5927\u53ef\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u7684\u764c\u75c7\u60a3\u8005\u4eba\u7fa4\u3002<\/p>\n\n\n\n 2021\u5e74\u521d\uff0cJS006\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u83b7\u51c6\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002\u540c\u5e74\uff0c\u541b\u5b9e\u751f\u7269\u542f\u52a8\u4e00\u9879I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30JS006\u5355\u836f\u53ca\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u6216\u6ca1\u6709\u6807\u51c6\u6cbb\u7597\u7684\u665a\u671f\u80bf\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u541b\u5b9e\u751f\u7269\u4e0eCoherus\u6b63\u8ba1\u5212\u5728\u5317\u7f8e\u5f00\u5c55JS006\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u540e\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n\n\n \u5173\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297<\/strong><\/p>\n\n\n\n \u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\u00ae<\/sup>\uff09\u4f5c\u4e3a\u6211\u56fd\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u4e2a\u56fd\u4ea7\u4ee5PD-1\u4e3a\u9776\u70b9\u7684\u5355\u6297\u836f\u7269\uff0c\u83b7\u5f97\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u9879\u76ee\u652f\u6301\u3002\u672c\u54c1\u83b7\u6279\u7684\u7b2c\u4e00\u4e2a\u9002\u5e94\u75c7\u4e3a\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\uff0c\u76ee\u524d\u5df2\u67093\u9879\u9002\u5e94\u75c7\u7eb3\u5165\u300a2021\u5e74\u836f\u54c1\u76ee\u5f55\u300b\u30022021\u5e742\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\u30022021\u5e744\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u83b7\u5f97NMPA\u6279\u51c6\uff0c\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u30022021\u5e7411\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u83b7\u5f97NMPA\u6279\u51c6\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8fd8\u83b7\u5f97\u4e86\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u9ed1\u8272\u7d20\u7624\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u5934\u9888\u90e8\u80bf\u7624\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u9f3b\u54bd\u764c\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u5c3f\u8def\u4e0a\u76ae\u764c\u8bca\u7597\u6307\u5357\u300b\u53ca\u300aCSCO\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6307\u5357\u300b\u63a8\u8350\u3002<\/p>\n\n\n\n 2021\u5e743\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u665a\u671f\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u7684\u4e00\u7ebf\u6cbb\u7597\u88ab\u56fd\u5bb6\u836f\u76d1\u5c40\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u7a0b\u5e8f\u30022021\u5e747\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u542b\u94c2\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97NMPA\u53d7\u7406\u30022021\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6807\u51c6\u4e00\u7ebf\u5316\u7597\u7528\u4e8e\u672a\u7ecf\u6cbb\u7597\u3001\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97NMPA\u53d7\u7406\u3002\u5728\u56fd\u9645\u5316\u5e03\u5c40\u65b9\u9762\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u9996\u4e2a\u4e0a\u5e02\u7533\u8bf7\uff08BLA\uff09\u5df2\u83b7\u53d7\u7406\u5e76\u88ab\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u4e5f\u662f\u9996\u4e2a\u5411FDA\u63d0\u4ea4BLA\u7684\u56fd\u4ea7\u6297PD-1\u5355\u6297\u3002\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u3001\u9f3b\u54bd\u764c\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u98df\u7ba1\u764c\u9886\u57df\u83b7\u5f97FDA\u6388\u4e882\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u30011\u9879\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u30011\u9879\u4f18\u5148\u5ba1\u8bc4\u8ba4\u5b9a\u548c4\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n\n\n\n \u7279\u745e\u666e\u5229\u5355\u6297\u81ea2016\u5e74\u521d\u5f00\u59cb\u4e34\u5e8a\u7814\u53d1\uff0c\u81f3\u4eca\u5df2\u5728\u5168\u7403\u5f00\u5c55\u4e86\u8986\u76d6\u8d85\u8fc715\u4e2a\u9002\u5e94\u75c7\u768430\u591a\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u79ef\u6781\u63a2\u7d22\u672c\u54c1\u5728\u9ed1\u8272\u7d20\u7624\u3001\u9f3b\u54bd\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u80ba\u764c\u3001\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u809d\u764c\u3001\u80c6\u7ba1\u764c\u3001\u4e73\u817a\u764c\u3001\u80be\u764c\u7b49\u9002\u5e94\u75c7\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u4e0e\u56fd\u5185\u5916\u9886\u5148\u521b\u65b0\u836f\u4f01\u7684\u8054\u5408\u7597\u6cd5\u5408\u4f5c\u4e5f\u5728\u8fdb\u884c\u5f53\u4e2d\uff0c\u671f\u5f85\u8ba9\u66f4\u591a\u4e2d\u56fd\u4ee5\u53ca\u5176\u5b83\u56fd\u5bb6\u7684\u60a3\u8005\u83b7\u5f97\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n\n\n","protected":false},"excerpt":{"rendered":" \u5317\u4eac\u65f6\u95f42022\u5e741\u670810\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u4e0eCoherus BioSciences\uff08NASDAQ\uff1aCHRS\uff09\u5171\u540c\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c06\u6269\u5927\u4e8e2021\u5e74\u8fbe\u6210\u7684\u80bf\u7624\u514d\u75ab\u9886\u57df\u5408\u4f5c\uff0cCoherus\u5df2\u542f\u52a8\u884c\u4f7fJS006\uff08\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u6297TIGIT\u5355\u6297\uff09\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u7684\u8bb8\u53ef\u9009\u62e9\u6743\u7684\u7a0b\u5e8f\u3002\u5728\u9075\u5b88\u9002\u7528\u6cd5\u5f8b\u53ca\u6ee1\u8db3\u53cc\u65b9\u4e66\u9762\u7ea6\u5b9a\u7684\u6761\u4ef6\u7684\u524d\u63d0\u4e0b\uff0cCoherus\u5c06\u5411\u541b\u5b9e\u751f\u7269\u652f\u4ed83500\u4e07\u7f8e\u5143\u9996\u4ed8\u6b3e\uff0c\u6700\u9ad8\u8fbe2.55\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u3001\u7533\u62a5\u548c\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u4ea7\u54c1\u9500\u552e\u51c0\u989d18%\u7684\u9500\u552e\u5206\u6210\u3002\u9884\u8ba1\u4ea4\u6613\u5c06\u5728\u9002\u7528\u6cd5\u5f8b\u8981\u6c42\u7684\u653f\u5e9c\u624b\u7eed\u5b8c\u6bd5\u540e\u5b8c\u6210\u3002<\/p>\n","protected":false},"author":3,"featured_media":1664,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"yoast_head":"\n