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\u5317\u4eac\u65f6\u95f42023\u5e745\u67087\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff08EXTENTORCH\u7814\u7a76\uff09\u7684\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u8fbe\u5230\u65b9\u6848\u9884\u8bbe\u7684\u4f18\u6548\u8fb9\u754c\u3002\u541b\u5b9e\u751f\u7269\u8ba1\u5212\u5c06\u4e8e\u8fd1\u671f\u5411\u76d1\u7ba1\u90e8\u95e8\u9012\u4ea4\u8be5\u65b0\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n\n\n\n

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EXTENTORCH\u7814\u7a76\uff08NCT04012606\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u53ca\u94c2\u7c7b\u5728\u4e00\u7ebf\u6cbb\u7597ES-SCLC\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002EXTENTORCH\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u76f8\u6bd4\u5355\u7eaf\u5316\u7597\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597ES-SCLC\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u5b89\u5168\u6027\u6570\u636e\u4e0e\u65e2\u5f80\u7814\u7a76\u76f8\u4f3c\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u672c\u7814\u7a76\u7684\u8be6\u7ec6\u6570\u636e\u5c06\u5728\u8fd1\u671f\u7684\u56fd\u9645\u5b66\u672f\u5927\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n\n\n\n

EXTENTORCH<\/strong>\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u5ea6\u6076\u6027\u7684\u80ba\u90e8\u80bf\u7624\uff0cSCLC\u5f80\u5f80\u53d1\u73b0\u65f6\u5df2\u662f\u4e2d\u665a\u671f\uff0c\u7279\u522b\u662fES-SCLC\u4eba\u7fa4\uff0c\u5373\u4fbf\u5bf9\u5316\u7597\u7b49\u4f20\u7edf\u7597\u6cd5\u9ad8\u5ea6\u654f\u611f\uff0c\u4e5f\u6781\u6613\u5728\u77ed\u671f\u6cbb\u7597\u540e\u53d1\u751f\u8010\u836f\uff0c\u9884\u540e\u6781\u5dee\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u4ee5PD-(L)1\u4e3a\u4ee3\u8868\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e3aSCLC\u6cbb\u7597\u5e26\u6765\u8f6c\u673a\u3002EXTENTORCH\u7814\u7a76\u8bc1\u5b9e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u80fd\u591f\u6539\u5584ES-SCLC\u60a3\u8005\u7684\u751f\u5b58\uff0c\u8fdb\u4e00\u6b65\u786e\u7acb\u4e86PD-1\u6291\u5236\u5242\u4f5c\u4e3aES-SCLC\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u836f\u7269\u7684\u5730\u4f4d\u3002\u671f\u5f85\u7279\u745e\u666e\u5229\u5355\u6297\u80fd\u591f\u4e3a\u5e7f\u5927SCLC\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\uff01\u201d<\/p>\n\n\n\n

\u541b\u5b9e\u751f\u7269\u5168\u7403\u7814\u53d1\u603b\u88c1\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u4eca\u5e74\u4ee5\u6765\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u8fde\u7eed\u67094\u9879III\u671f\u4e34\u5e8a\u7814\u7a76\u53d6\u5f97\u6210\u529f\uff0c\u8fd9\u79bb\u4e0d\u5f00\u60a3\u8005\u548c\u5bb6\u5c5e\u7684\u5949\u732e\u7cbe\u795e\uff0c\u4ee5\u53ca\u7814\u7a76\u56e2\u961f\u7684\u503e\u60c5\u6295\u5165\u3002\u9488\u5bf9\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u6076\u6027\u80bf\u7624\u4e2d\u7684\u2018\u5934\u53f7\u5a01\u80c1\u2019\u80ba\u764c\uff0c\u541b\u5b9e\u751f\u7269\u56f4\u7ed5\u75be\u75c5\u4e9a\u578b\u3001\u5206\u671f\u3001\u836f\u7269\u9776\u70b9\u8fdb\u884c\u4e86\u5168\u9762\u3001\u524d\u77bb\u6027\u7684\u7814\u53d1\u5e03\u5c40\uff0c\u4ece\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5230\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u4ece\u665a\u671f\u5230\u56f4\u624b\u672f\u671f\u6cbb\u7597\uff0c\u4ecePD-1\u5230BTLA\uff0c\u4e00\u6b65\u6b65\u9769\u65b0\u80ba\u764c\u7684\u6807\u51c6\u6cbb\u7597\u6a21\u5f0f\uff0c\u52aa\u529b\u4e3a\u5168\u7403\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u3001\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201c<\/p>\n\n\n\n

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\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1.    Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 Feb 4.<\/h5>\n\n\n\n
2.     \u5f20\u723d\u7b49.\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2a\u4f53\u5316\u6cbb\u7597\u8fdb\u5c55[J].\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a,2017,44(12):571-576.<\/h5>\n\n\n\n
3.     Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.<\/h5>\n\n\n\n
4.     Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.<\/h5>\n\n\n\n
5.     Kalemkerian GP. Small Cell Lung Cancer. Semin Respir Crit Care Med. 2016 Oct;37(5):783-796.<\/h5>\n\n\n\n
6.     Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.<\/h5>\n\n\n\n
7.     Lally BE, et al. Small cell lung cancer: have we made any progress over the last 25 years? Oncologist. 2007 Sep;12(9):1096-104.<\/h5>\n\n\n\n
8.     Socinski MA, et al. Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer. J Clin Oncol. 2009 Oct 1;27(28):4787-92.<\/h5>\n\n\n\n

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1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

\u5173\u4e8eEXTENTORCH\u7814\u7a76<\/strong><\/p>\n\n\n\n

EXTENTORCH\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u53ca\u94c2\u7c7b\u5728\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7531\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u526f\u7406\u4e8b\u957f\u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n\n\n\n

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