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\u5317\u4eac\u65f6\u95f42023\u5e746\u670828\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u4e8e\u8fd1\u65e5\u540c\u610f\u516c\u53f8\u5f00\u5c55\u6297BTLA\u5355\u6297tifcemalimab\uff08\u4ea7\u54c1\u4ee3\u53f7\uff1aTAB004\/JS004\uff09\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u4f5c\u4e3a\u5c40\u9650\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08LS-SCLC\uff09\u653e\u5316\u7597\u540e\u672a\u8fdb\u5c55\u60a3\u8005\u7684\u5de9\u56fa\u6cbb\u7597\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n

\u80ba\u764c\u662f\u76ee\u524d\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u6392\u540d\u9996\u4f4d\u7684\u6076\u6027\u80bf\u76241<\/sup>\uff0c\u6309\u7ec6\u80de\u7c7b\u578b\u5927\u81f4\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u3002\u5176\u4e2d\uff0cSCLC\u662f\u80ba\u764c\u4e2d\u4fb5\u88ad\u6027\u6700\u5f3a\u7684\u4e9a\u578b2<\/sup>\uff0c\u7ea6\u5360\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u768415%-20%3<\/sup>\uff0c\u5177\u6709\u8fdb\u5c55\u8fc5\u901f\u3001\u65e9\u671f\u8f6c\u79fb\u3001\u9884\u540e\u5dee\u7b49\u7279\u70b94<\/sup>\u3002SCLC\u5206\u4e3a\u5c40\u9650\u671f\uff08LS-SCLC\uff09\u548c\u5e7f\u6cdb\u671f\uff08ES-SCLC\uff09\uff0c\u5176\u4e2d\uff0cLS-SCLC\u7ea6\u5360\u4e09\u5206\u4e4b\u4e005<\/sup>\u3002\u5bf9\u4e8e\u65e0\u6cd5\u624b\u672f\u6216\u62d2\u7edd\u624b\u672f\u7684LS-SCLC\u60a3\u8005\uff0c\u540c\u6b65\u653e\u5316\u7597\uff08CRT\uff09\u4e3a\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u3002\u4f46\u662f\u8fd9\u7c7b\u60a3\u8005\u5373\u4fbf\u63a5\u53d7\u6807\u51c6\u540c\u6b65\u653e\u5316\u7597\uff0c\u9884\u540e\u4ecd\u8f83\u5dee\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7ea6\u4e3a13.5\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u572816-24\u4e2a\u6708\uff0c5\u5e74\u751f\u5b58\u7387\u4ec515%-26%6<\/sup>\uff0c7<\/sup>\u3002LS-SCLC\u7684\u6cbb\u7597\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u6cbb\u7597\u9700\u6c42\uff0c\u4e34\u5e8a\u4e9f\u9700\u63a2\u7d22\u7597\u6548\u66f4\u4f18\u3001\u8010\u53d7\u6027\u826f\u597d\u7684\u65b9\u6848\u3002<\/p>\n\n\n\n

\u541b\u5b9e\u751f\u7269\u8ba1\u5212\u4e8e\u8fd1\u671f\u542f\u52a8\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30tifcemalimab\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5bf9\u6bd4\u7279\u745e\u666e\u5229\u5355\u6297\u5355\u836f\u53ca\u5bf9\u6bd4\u5b89\u6170\u5242\u7528\u4e8eCRT\u540e\u672a\u8fdb\u5c55LS-SCLC\u60a3\u8005\u7684\u5de9\u56fa\u6cbb\u7597\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u4e3aBTLA\u9776\u70b9\u836f\u7269\u9996\u4e2a\u786e\u8bc1\u6027\u7814\u7a76\uff0c\u5c06\u7531\u5c71\u4e1c\u7b2c\u4e00\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u9662\u957f\u4e8e\u91d1\u660e\u9662\u58eb\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u8ba1\u5212\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u7b49\u5730\u5165\u7ec4756\u4f8b\u60a3\u8005\u3002<\/p>\n\n\n\n

\u541b\u5b9e\u751f\u7269\u5168\u7403\u7814\u53d1\u603b\u88c1\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u8fd1\u5e74\u6765\uff0c\u80bf\u7624\u514d\u75ab\uff08I-O\uff09\u6cbb\u7597\u53d1\u5c55\u8fc5\u901f\uff0c\u5c24\u5176\u5728\u80ba\u764c\u9886\u57df\u5df2\u6210\u4e3a\u665a\u671fNSCLC\u7684\u4e00\u7ebf\u6cbb\u7597SOC\u3002\u800c\u5bf9\u4e8e\u4fb5\u88ad\u6027\u66f4\u5f3a\u7684SCLC\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u7814\u7a76\u8fdb\u5c55\u8f83\u4e3a\u7f13\u6162\uff0c\u5168\u7403\u8303\u56f4\u5185\u5c1a\u65e0\u4efb\u4f55\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u83b7\u6279\u7528\u4e8eLS-SCLC\u3002Tifcemalimab\u4f5c\u4e3a\u541b\u5b9e\u751f\u7269\u9996\u6b3e\u81ea\u4e3b\u7814\u53d1\u7684\u2018\u5168\u7403\u65b0\u2019\uff08first-in-class\uff09\u4ea7\u54c1\uff0c\u6709\u671b\u4e0e\u6211\u4eecI-O\u7ba1\u7ebf\u4e0a\u7684\u57fa\u77f3\u7c7b\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u5f3a\u5f3a\u8054\u5408\uff0c\u63d0\u5347\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94\uff0c\u6269\u5927\u53ef\u80fd\u53d7\u76ca\u4eba\u7fa4\u7684\u8303\u56f4\uff0c\u4e3aLS-SCLC\u4eba\u7fa4\u7684\u6cbb\u7597\u683c\u5c40\u5e26\u6765\u65b0\u7a81\u7834\uff01\u201d<\/p>\n\n\n\n

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\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 Feb 4.<\/h5>\n\n\n\n
2.\u5f20\u723d\u7b49.\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2a\u4f53\u5316\u6cbb\u7597\u8fdb\u5c55[J].\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a,2017,44(12):571-576.<\/h5>\n\n\n\n
3.Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.<\/h5>\n\n\n\n
4.Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.<\/h5>\n\n\n\n
5.Thatcher N, et al. Management of small-cell lung cancer. Ann Oncol. 2005;16 Suppl 2:ii235-9.<\/h5>\n\n\n\n
6.Faivre-Finn C, et al. Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial. Lancet Oncol. 2017 Aug;18(8):1116-1125.<\/h5>\n\n\n\n
7.Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.<\/h5>\n\n\n\n

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1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
2. <\/em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/strong><\/h6>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

\u5173\u4e8etifcemalimab\uff08TAB004\/JS004\uff09<\/strong><\/p>\n\n\n\n

Tifcemalimab\uff08TAB004\/JS004\uff09\u662f\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff08first-in-human\uff09\u7684\u6297\u80bf\u7624\u91cd\u7ec4\u4eba\u6e90\u5316\u6297BTLA\uff08B\u548cT\u6dcb\u5df4\u7ec6\u80de\u8870\u51cf\u56e0\u5b50\uff09\u5355\u514b\u9686\u6297\u4f53\u3002\u76ee\u524d\uff0ctifcemalimab\u5df2\u83b7\u51c6\u8fdb\u5165III\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u53e6\u6709\u591a\u9879\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u7684Ib\/II\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u540c\u6b65\u5f00\u5c55\u4e2d\uff0c\u8986\u76d6\u591a\u4e2a\u7624\u79cd\u3002<\/p>\n\n\n\n

Tifcemalimab\u6240\u9488\u5bf9\u7684BTLA\u9776\u70b9\u4e8e2003\u5e74\u53d1\u73b0\uff0c\u4e3aCD28\u53d7\u4f53\u5bb6\u65cf\u6210\u54581<\/sup>\u3002\u5b83\u5177\u6709\u5355\u4e2aIgSF V\u7ec6\u80de\u5916\u57df\uff0c\u5176\u5e8f\u5217\u4e0e\u5176\u4ed6CD28\u5bb6\u65cf\u5206\u5b50\uff08\u4f8b\u5982PD-1\u548cCTLA-4\uff09\u5177\u6709\u76f8\u4f3c\u6027\u3002<\/p>\n\n\n\n

BTLA\u5728T\u548cB\u6dcb\u5df4\u7ec6\u80de\u4ee5\u53ca\u6811\u7a81\u72b6\u7ec6\u80de\u4e9a\u7fa4\u4e0a\u8868\u8fbe\u3002BTLA\u4e0e\u5176\u914d\u4f53HVEM\uff08Herpes virus entry mediator\uff0c\u75b1\u75b9\u75c5\u6bd2\u4fb5\u5165\u4ecb\u8d28\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u4e8e2005\u5e74\u88ab\u53d1\u73b0\uff0cHVEM\u662f\u5728\u9020\u8840\u7cfb\u7edf\u4e2d\u5e7f\u6cdb\u8868\u8fbe\u7684TNF\u53d7\u4f53\uff0c\u88ab\u786e\u5b9a\u4e3aBTLA\u7684\u914d\u4f532<\/sup>\u3002<\/p>\n\n\n\n

BTLA\u662f\u4e00\u79cd\u514d\u75ab\u7403\u86cb\u767d\u76f8\u5173\u6027\u819c\u86cb\u767d\uff0c\u5176\u86cb\u767d\u7ed3\u6784\u7c7b\u4f3c\u4e8e\u8de8\u819c\u53d7\u4f53CTLA-4\u548cPD-1\u3002\u5728\u6b63\u5e38\u751f\u7406\u60c5\u51b5\u4e0b\uff0cBTLA\u4e0e\u5176\u914d\u4f53HVEM\u7ed3\u5408\u540e\uff0c\u53ef\u4ee5\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\uff0c\u9632\u6b62\u514d\u75ab\u7cfb\u7edf\u5bf9\u81ea\u8eab\u7684\u635f\u4f242<\/sup>\u3002<\/p>\n\n\n\n

Tifcemalimab\u901a\u8fc7\u7ed3\u5408BTLA\uff0c\u963b\u65adHVEM-BTLA\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u963b\u65adBTLA\u4ecb\u5bfc\u7684\u6291\u5236\u6027\u4fe1\u53f7\u901a\u8def\uff0c\u6700\u7ec8\u8fbe\u5230\u6fc0\u6d3b\u80bf\u7624\u7279\u5f02\u6dcb\u5df4\u7ec6\u80de\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1. Watanabe, N., Gavrieli, M., Sedy, J.R., Yang,J., Fallarino, F., Loftin, S.K., Hurchla, M.A., Zimmerman, N., Sim, J., Zang, X., et al. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4, 670-679.<\/h5>\n\n\n\n
2. Sedy, J.R., Gavrieli, M., Potter, K.G., Hurchla, M.A., Lindsley, R.C., Hildner, K., Scheu, S., Pfeffer, K., Ware, C.F., Murphy, T.L., et al. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 6, 90-98.<\/h5>\n\n\n\n

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\u5173\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\u00ae<\/sup>\uff09<\/strong><\/p>\n\n\n\n

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