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\u6b64\u524d\uff0cRENOTORCH\u7684\u7814\u7a76\u6210\u679c\u57282023\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4f18\u9009\u53e3\u5934\u62a5\u544a\u4e13\u573a\u4f1a\u8bae\u4e0a\u9996\u6b21\u53d1\u5e03\uff0c\u5168\u6587\u540c\u6b65\u83b7ESMO\u5b98\u65b9\u671f\u520a\u300a\u80bf\u7624\u5b66\u5e74\u9274\u300b\uff08Annals of Oncology<\/em>\uff1b\u5f71\u54cd\u56e0\u5b50\uff1a50.5\uff1b\u80bf\u7624\u9886\u57df\u5168\u7403\u6392\u540dTOP5\u7684\u9876\u7ea7\u671f\u520a\uff09\u53d1\u8868\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u57fa\u4e8eIRC\u8bc4\u4f30\u7ed3\u679c\uff0c\u4e0e\u8212\u5c3c\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u63a5\u53d7\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u6cbb\u7597\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684PFS\uff08\u4e2d\u4f4dPFS\uff1a18.0 vs. 9.8\u4e2a\u6708\uff0cP=0.0028\uff09\uff0c\u60a3\u8005PFS\u5ef6\u957f\u8fd12\u500d\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e35%\uff08\u98ce\u9669\u6bd4[HR]=0.65\uff1b95%CI\uff1a0.49\uff0c0.86\uff09\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684ORR\u66f4\u4f18\uff0856.7% vs. 30.8%\uff0cP<0.0001\uff09\uff0c\u5e76\u4e14DoR\u66f4\u957f\uff08\u4e2d\u4f4dDoR\uff1a\u672a\u8fbe\u5230 vs. 16.7\u4e2a\u6708\uff1bHR=0.61\uff09\uff0c\u5177\u6709\u660e\u663e\u7684OS\u83b7\u76ca\u8d8b\u52bf\uff08\u4e2d\u4f4dOS\uff1a\u672a\u8fbe\u5230 vs. 26.8\u4e2a\u6708\uff09\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e39%\uff08HR=0.61\uff1b95%CI\uff1a0.40\uff0c0.92\uff09\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n

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\u541b\u5b9e\u751f\u7269\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u6267\u884c\u5b98\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u611f\u8c22\u6240\u6709\u53c2\u4e0eRENOTORCH\u7814\u7a76\u7684\u533b\u52a1\u5de5\u4f5c\u8005\u3001\u60a3\u8005\u4ee5\u53ca\u7814\u53d1\u4eba\u5458\u7684\u5949\u732e\uff0c\u8ba9\u4e2d\u56fd\u80be\u764c\u514d\u75ab\u6cbb\u7597\u5b9e\u73b0\u2018\u96f6\u7684\u7a81\u7834\u2019\uff01\u541b\u5b9e\u751f\u7269\u5c06\u7ee7\u7eed\u7acb\u8db3\u4e8e\u56fd\u4eba\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u6301\u7eed\u6295\u5165\u521b\u65b0\u7814\u53d1\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u83b7\u5f97\u66f4\u597d\u7684\u751f\u5b58\u8d28\u91cf\u548c\u66f4\u957f\u4e45\u7684\u751f\u5b58\u83b7\u76ca\uff01\u201d<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1. \u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a. \u300a\u80be\u7ec6\u80de\u764c\u8bca\u7597\u6307\u5357\uff082022\u5e74\u7248\uff09\u300b. 2022.<\/h5>\n\n\n\n
2. Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl) 2022;135:584-90.<\/h5>\n\n\n\n
3. Padala SA, Barsouk A, Thandra KC, et al. Epidemiology of Renal Cell Carcinoma. World J Oncol 2020;11:79-87.<\/h5>\n\n\n\n
4. Janzen NK, Kim HL, Figlin RA, Belldegrun AS. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am 2003;30:843-52.<\/h5>\n\n\n\n
5. Heng DY, Xie W, Regan MM, et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol 2009; 27:5794-9.<\/h5>\n\n\n\n

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1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n
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