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\u5317\u4eac\u65f6\u95f42024\u5e746\u670812\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\u00ae\uff09\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u94c2\u7c7b\u7528\u4e8e\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u4e8e\u8fd1\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002\u8fd9\u662f\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u56fd\u5185\u5730\u83b7\u6279\u7684\u7b2c\u4e5d\u9879\u9002\u5e94\u75c7\u3002<\/p>\n\n\n\n


\u80ba\u764c\u662f\u76ee\u524d\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u6392\u540d\u9996\u4f4d\u7684\u6076\u6027\u80bf\u7624[1]<\/sup>\u3002\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u662f\u80ba\u764c\u4e2d\u4fb5\u88ad\u6027\u6700\u5f3a\u7684\u4e9a\u578b[2]<\/sup>\uff0c\u7ea6\u5360\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u768415%-20%[3]<\/sup>\uff0c\u5177\u6709\u8fdb\u5c55\u8fc5\u901f\u3001\u65e9\u671f\u8f6c\u79fb\u3001\u9884\u540e\u5dee\u7b49\u7279\u70b9[4]<\/sup>\u3002SCLC\u5206\u4e3a\u5c40\u9650\u671f\uff08LS-SCLC\uff09\u548c\u5e7f\u6cdb\u671f\uff08ES-SCLC\uff09\u3002\u5bf9\u4e8eLS-SCLC\u60a3\u8005\uff0c\u901a\u8fc7\u6807\u51c6\u5316\u7597\u548c\u653e\u7597\uff0c\u76ee\u524d\u5df2\u53ef\u8fbe\u5230\u7ea690%\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u7ea625%\u76845\u5e74\u751f\u5b58\u7387[5,6]<\/sup>\u3002\u7136\u800c\uff0c\u5927\u90e8\u5206\u60a3\u8005\u5728\u5c31\u8bca\u65f6\uff0c\u5df2\u88ab\u8bca\u65ad\u4e3aES-SCLC\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e0d\u8db31\u5e74[7]<\/sup>\uff0c2\u5e74\u751f\u5b58\u7387\u4e0d\u523010%[8]\uff0c\u4ecd\u662f\u4e34\u5e8a\u672a\u89e3\u51b3\u7684\u4e00\u5927\u96be\u9898\u3002<\/p>\n\n\n\n


\u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u7684\u83b7\u6279\u4e3b\u8981\u57fa\u4e8eEXTENTORCH\u7814\u7a76\uff08NCT04012606\uff09\u7684\u6570\u636e\u7ed3\u679c\u3002EXTENTORCH\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u53ca\u94c2\u7c7b\u5728\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u7531\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388<\/strong>\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u5168\u56fd51\u5bb6\u4e34\u5e8a\u4e2d\u5fc3\u8054\u5408\u5f00\u5c55\u3002<\/p>\n\n\n\n


2023\u5e745\u6708\uff0cEXTENTORCH\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u8fbe\u5230\u65b9\u6848\u9884\u8bbe\u7684\u4f18\u6548\u8fb9\u754c\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7531\u6b64\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u5728ES-SCLC\u4e00\u7ebf\u6cbb\u7597III\u671f\u7814\u7a76\u4e2d\u8fbe\u6210\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9\u7684PD-1\u6291\u5236\u5242\u3002
2023\u5e7410\u6708\u4e3e\u884c\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4e0a\uff0cEXTENTORCH\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u9996\u6b21\u516c\u5e03\u6570\u636e\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u76f8\u8f83\u5355\u7eaf\u5316\u7597\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684PFS\u548cOS\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\uff0c\u6709\u671b\u6210\u4e3aES-SCLC\u514d\u75ab\u6cbb\u7597\u7684\u4f18\u9009\u65b9\u6848\u3002\u5176\u4e2d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dPFS\u8fbe5.8\u4e2a\u6708\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e33.3%\uff08P=0.0002\uff09\uff0c1\u5e74PFS\u7387\u8f83\u5316\u7597\u7ec4\u63d0\u5347\u8fd14\u500d\uff0818.1% vs. 4.9%\uff09\uff1b\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dOS\u8fbe14.6\u4e2a\u6708\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e20.2%\uff08P=0.0327\uff09\uff0c1\u5e74OS\u7387\u9ad8\u8fbe63.1%\u3002<\/p>\n\n\n\n


\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201cSCLC\u4fb5\u88ad\u6027\u5f3a\u3001\u65e9\u671f\u8f6c\u79fb\u548c\u8f83\u5dee\u7684\u9884\u540e\u3002\u957f\u671f\u4ee5\u6765\uff0cES-SCLC\u90fd\u4ee5\u542b\u94c2\u5316\u7597\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u5c3d\u7ba1\u60a3\u8005\u7528\u836f\u521d\u671f\u8f83\u654f\u611f\uff0c\u4f46\u6613\u51fa\u73b0\u8010\u836f\uff0c\u800c\u514d\u75ab\u6cbb\u7597\u7684\u52a0\u5165\u6253\u5f00\u4e86\u65b0\u7684\u5c40\u9762\u3002EXTENTORCH\u7814\u7a76\u7684PFS\u548cOS\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9\u8bbe\u8ba1\u9075\u5faa\u4e86\u66f4\u9ad8\u7684\u7edf\u8ba1\u5b66\u6807\u51c6\uff0c\u5e76\u6700\u7ec8\u53d6\u5f97\u4e86\u53cc\u7ec8\u70b9\u9633\u6027\u7ed3\u679c\uff0c\u8fd9\u610f\u5473\u7740\u76f8\u8f83\u5355\u7eaf\u5316\u7597\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u7684PFS\u548cOS\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u83b7\u6279ES-SCLC\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\uff0c\u4e3a\u4e2d\u56fdSCLC\u589e\u6dfb\u4e86\u65b0\u7684\u3001\u6709\u6548\u7684\u3001\u5b89\u5168\u6027\u7684\u3001\u7ecf\u6d4e\u7684\u6cbb\u7597\u9009\u62e9\uff01\u201d<\/p>\n\n\n\n

\u541b\u5b9e\u751f\u7269\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u6267\u884c\u5b98\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u5168\u7403\u65b0\u53d1\u548c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u6700\u9ad8\u7684\u764c\u75c7\uff0c\u80ba\u764c\u4e00\u76f4\u662f\u80bf\u7624\u6cbb\u7597\u7684\u2018\u5934\u53f7\u654c\u4eba\u2019\u3002\u541b\u5b9e\u751f\u7269\u5728\u80ba\u764c\u65b0\u836f\u7814\u53d1\u4e0a\u6301\u7eed\u6295\u5165\uff0c\u622a\u81f3\u76ee\u524d\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u6210\u529f\u83b7\u62793\u9879\u80ba\u764c\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548cSCLC\uff0c\u5e76\u8986\u76d6\u4e86\u65e9\u4e2d\u671f\uff08\u56f4\u624b\u672f\u671f\uff09\u81f3\u665a\u671f\u4eba\u7fa4\uff0c\u8fd8\u6709\u66f4\u591a\u4ea7\u54c1\u548c\u9002\u5e94\u75c7\u4ecd\u5904\u4e8e\u653b\u5173\u9636\u6bb5\u3002\u6211\u4eec\u4e5f\u671f\u5f85\u80fd\u591f\u4e0d\u65ad\u4e3a\u80ba\u764c\u60a3\u8005\u5e26\u6765\u66f4\u591a\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n\n\n\n

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\u3010\u53c2\u8003\u6587\u732e\u3011<\/h6>\n\n\n\n
1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h6>\n\n\n\n
2. \u5f20\u723d\u7b49.\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2a\u4f53\u5316\u6cbb\u7597\u8fdb\u5c55[J].\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a,2017,44(12):571-576.<\/h6>\n\n\n\n
3. Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.<\/h6>\n\n\n\n
4. Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.<\/h6>\n\n\n\n
5. Kalemkerian GP. Small Cell Lung Cancer. Semin Respir Crit Care Med. 2016 Oct;37(5):783-796.<\/h6>\n\n\n\n
6. Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.<\/h6>\n\n\n\n
7. Lally BE, et al. Small cell lung cancer: have we made any progress over the last 25 years? Oncologist. 2007 Sep;12(9):1096-104.<\/h6>\n\n\n\n
8. Socinski MA, et al. Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer. J Clin Oncol. 2009 Oct 1;27(28):4787-92.
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1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

\u5173\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\u00ae<\/sup>\uff09<\/strong>
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