{"id":58,"date":"2022-11-15T07:11:00","date_gmt":"2022-11-15T07:11:00","guid":{"rendered":"https:\/\/dianhuaminglu.com\/?p=58"},"modified":"2023-05-04T10:27:15","modified_gmt":"2023-05-04T10:27:15","slug":"junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2","status":"publish","type":"post","link":"https:\/\/dianhuaminglu.com\/junshi-biology-was-successfully-listed-on-the-main-board-of-hong-kong-stock-exchange-4-2\/","title":{"rendered":"\u541b\u5b9e\u751f\u7269\u5ba3\u5e03\u5df2\u5411\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u63d0\u4ea4\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><em>\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8eNPC\u548cESCC\u4e00\u7ebf\u6cbb\u7597MAA\u5728\u6b27\u76df\u5b8c\u6210\u63d0\u4ea4<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>\u7ee7\u4e2d\u56fd\u548c\u7f8e\u56fd\u4e4b\u540e\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u5168\u7403\u5546\u4e1a\u5316\u5e03\u5c40\u5f00\u59cb\u5411\u6b27\u6d32\u62d3\u5c55<\/em><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5317\u4eac\u65f6\u95f42022\u5e7411\u670815\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5c31\u7279\u745e\u666e\u5229\u5355\u6297\u5411\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u63d0\u4ea4\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\uff0c\u9002\u5e94\u75c7\u5206\u522b\u4e3a\uff1a<\/p>\n\n\n\n<p>1. \u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/p>\n\n\n\n<p>2. 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Keegan\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u4ece\u4e2d\u56fd\u5230\u7f8e\u56fd\u518d\u5230\u6b27\u6d32\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u5168\u7403\u5546\u4e1a\u5316\u5de5\u4f5c\u6b63\u5728\u6709\u5e8f\u5f00\u5c55\u3002\u6b64\u6b21\u9012\u4ea4\u5f52\u529f\u4e8e\u8be5\u836f\u7269\u5728NPC\u548cESCC\u6cbb\u7597\u4e2d\u89c2\u5bdf\u5230\u4e86\u624e\u5b9e\u7684\u7597\u6548\uff0c\u5e76\u5728\u591a\u79cd\u80bf\u7624\u6cbb\u7597\u65b9\u9762\u663e\u793a\u51fa\u4f18\u826f\u7684\u5b89\u5168\u6027\u3002\u7279\u522b\u5bf9\u4e8e\u4e9f\u5f85\u89e3\u51b3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5c24\u5176\u5177\u6709\u5f71\u54cd\u529b\u3002\u4f8b\u5982\u5728\u4e00\u9879\u968f\u673a\u3001\u786e\u8bc1\u6027\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u8bc1\u5b9e\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u80fd\u591f\u4e3a\u9f3b\u54bd\u764c\u60a3\u8005\u5e26\u6765\u5f3a\u5927\u7684\u751f\u5b58\u6539\u5584\u8d8b\u52bf\uff0c\u5c06\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5ef6\u957f\u4e8613.2\u4e2a\u6708\u3002\u540c\u6837\u7684\uff0c\u968f\u673a\u7814\u7a76\u8bc1\u5b9e\uff0c\u5728\u7d2b\u6749\u9187\u5316\u7597\u57fa\u7840\u4e0a\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u663e\u8457\u6539\u5584\u4e86ESCC\u60a3\u8005\u7684\u751f\u5b58\u671f\u548cPFS\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6211\u4eec\u5728PD-L1\u4f4e\u8868\u8fbe\u7684\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u7597\u6548\uff0c\u5373\u4f7f\u8fd9\u7c7b\u4eba\u7fa4\u4f7f\u7528\u5176\u4ed6ICI\u836f\u7269\u53ef\u80fd\u7597\u6548\u4e0d\u4f73\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c06\u4e0e\u6b27\u6d32\u76d1\u7ba1\u673a\u6784\u4fdd\u6301\u7d27\u5bc6\u6c9f\u901a\uff0c\u671f\u5f85\u5c3d\u5feb\u5c06\u7279\u745e\u666e\u5229\u5355\u6297\u5e26\u7ed9\u6b27\u6d32\u60a3\u8005\u3002\u201d<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u662f\u7531\u541b\u5b9e\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u3002\u6b64\u6b21\u9f3b\u54bd\u764c\u9002\u5e94\u75c7\u7684MAA\u63d0\u4ea4\u4e3b\u8981\u57fa\u4e8eJUPITER-02\uff08\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0cNCT03581786\uff09\u53caPOLARIS-02\uff08\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001II\u671f\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff0cNCT02915432\uff09\uff0c\u8d2f\u7a7f\u4e86\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7ebf\u81f3\u540e\u7ebf\u6cbb\u7597\u3002JUPITER-02\u7814\u7a76\u7ed3\u679c\u4e8e2021\u5e746\u6708\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u7684\u5168\u4f53\u5927\u4f1a\u4e0a\u9996\u6b21\u53d1\u8868\uff08#LBA2\uff09\uff0c\u968f\u540e\u4f5c\u4e3a<a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01444-0\">\u300a\u81ea\u7136-\u533b\u5b66\u300b<\/a>\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a87.241\uff092021\u5e749\u6708\u520a\u7684\u5c01\u9762\u6587\u7ae0\u53d1\u8868\u3002POLARIS-02\u7814\u7a76\u7ed3\u679c\u5df2\u4e8e2021\u5e741\u6708\u5728\u7ebf\u53d1\u8868\u4e8e<a href=\"https:\/\/ascopubs.org\/doi\/full\/10.1200\/JCO.20.02712\">\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b<\/a>\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a50.717\uff09\u3002<\/p>\n\n\n\n<p>2021\u5e74\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u4e24\u9879\u9f3b\u54bd\u764c\u65b0\u9002\u5e94\u75c7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u6279\u9f3b\u54bd\u764c\u6cbb\u7597\u7684ICI\u836f\u7269\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u4e5f\u9488\u5bf9\u5176\u9f3b\u54bd\u764c\u9002\u5e94\u75c7\u6388\u4e882\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c1\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5e76\u4e14\u53d7\u7406\u4e86\u8be5\u836f\u7269\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u3002\u5982\u82e5\u6279\u51c6\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5c06\u6210\u4e3a\u7f8e\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u836f\u7269\u30022022\u5e747\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u9f3b\u54bd\u764c\u83b7\u5f97\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u6709\u52a9\u4e8e\u541b\u5b9e\u751f\u7269\u4ece\u591a\u9879\u6fc0\u52b1\u63aa\u65bd\u4e2d\u83b7\u76ca\u3002<\/p>\n\n\n\n<p>\u6b64\u6b21\u98df\u7ba1\u9cde\u764c\u9002\u5e94\u75c7\u7684MAA\u63d0\u4ea4\u4e3b\u8981\u57fa\u4e8eJUPITER-06\uff08\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u7814\u7a76\uff0cNCT03829969\uff09\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u9996\u6b21\u5728\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\uff08ESMO 2021\uff09\u4e0a\u4ee5\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u62a5\u544a\uff0c\u968f\u540e\u5728\u56fd\u9645\u9876\u5c16\u80bf\u7624\u5b66\u6742\u5fd7<a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(22)00059-9\">\u300aCancer Cell\u300b<\/a>\uff08\u5f71\u54cd\u56e0\u5b50\uff1a38.585\uff09\u53d1\u8868\u30022022\u5e745\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u98df\u7ba1\u9cde\u764c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u98df\u7ba1\u764c\u4e5f\u66fe\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"has-small-font-size wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n\n\n<p><strong>\u5173\u4e8e\u9f3b\u54bd\u764c<\/strong><\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u79cd\u539f\u53d1\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u662f\u5e38\u89c1\u7684\u5934\u9888\u90e8\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7edf\u8ba1\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc713\u4e07<sup>[1]<\/sup>\u3002\u7531\u4e8e\u539f\u53d1\u80bf\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u91c7\u7528\u624b\u672f\u6cbb\u7597\uff0c\u5c40\u90e8\u75be\u75c5\u60a3\u8005\u4e3b\u8981\u91c7\u7528\u5316\u7597\u53ca\u653e\u7597\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\uff0c\u76ee\u524d\u5c1a\u65e0\u836f\u7269\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u9f3b\u54bd\u764c\uff0c\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7ebf\u6807\u51c6\u7597\u6cd5\uff08\u5409\u897f\u4ed6\u6ee8\/\u987a\u94c2\uff09\u662f\u57fa\u4e8e\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u968f\u673a\u7814\u7a76\u3002<\/p>\n\n\n\n<h5 class=\"has-small-font-size wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf<\/a>.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u5173\u4e8e\u98df\u7ba1\u764c<\/strong><\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9886\u57df\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u636e\u7edf\u8ba1\uff0c\u98df\u7ba1\u764c\u662f2020\u5e74\u5168\u7403\u7b2c\u4e03\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\u548c\u7b2c\u516d\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\uff0c\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc760\u4e07\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u8d85\u8fc754\u4e07<sup>[1]<\/sup>\u3002\u98df\u7ba1\u9cde\u764c\uff08ESCC\uff09\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u4e24\u79cd\u4e3b\u8981\u7ec4\u7ec7\u5b66\u4e9a\u578b\u3002\u65b0\u8fd1\u66f4\u65b0\u7684ESMO\u6307\u5357\u63a8\u8350\u94c2\u7c7b\u548c\u6c1f\u5c3f\u5627\u5576\u7c7b\u53cc\u836f\u8054\u5408PD-1\u963b\u65ad\u6027\u6297\u4f53\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC<sup>[2]<\/sup>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76ee\u524d\u5df2\u5728\u6b27\u7f8e\u83b7\u6279\u8be5\u9886\u57df\u6cbb\u7597\u7684\u514d\u75ab\u7597\u6cd5\u9002\u5e94\u75c7\u4ec5\u9002\u7528ESCC\u7684\u90e8\u5206\u4eba\u7fa4\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6848\u6765\u5ef6\u957fESCC\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u7279\u522b\u662fPD-L1\u4f4e\u8868\u8fbe\u4eba\u7fa4\u3002<\/p>\n\n\n\n<h5 class=\"has-small-font-size wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5 class=\"has-small-font-size wp-block-heading\">[1] <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/6-Oesophagus-fact-sheet.pdf<\/a>.<\/h5>\n\n\n\n<h5 class=\"has-small-font-size wp-block-heading\">[2] Obermannova R,Alsina M, Cervantes A,Leong T,Lordick F, Nilsson M,van Greeken NCT, Vogel A,Smyth EC; ESMO Guidelines Committee. ESMO Clinical Practice Guidline for diagnosis,treatment and follow-up.Ann Oncol.2022 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