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Medicinal 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2021\uff09\u5168\u9ad4\u5927\u6703\uff0c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a<a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01444-0\">\u300a\u81ea\u7136-\u91ab\u5b78\u300b<\/a>\u96dc\u8a8c\u5c01\u9762\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a87.241\uff09\uff0c\u7372\u5f97<a href=\"https:\/\/ascopubs.org\/doi\/full\/10.1200\/JCO.20.02712\">\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u8a8c\u300b<\/a>\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a50.717\uff09\u7dda\u4e0a\u767c\u8868\u3002<\/p>\n\n\n\n<p>\u57fa\u65bc\u4e0a\u8ff0\u5169\u9805\u7814\u7a76\u7d50\u679c\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u9678\u7e8c\u53d7\u5230\u4e2d\u570b\u548c\u6d77\u5916\u85e5\u54c1\u76e3\u7ba1\u6a5f\u69cb\u8a8d\u53ef\u30022021\u5e74\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u5169\u9805\u9f3b\u54bd\u764c\u65b0\u9069\u61c9\u75c7\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u6210\u70ba\u5168\u7403\u9996\u500b\u7372\u6279\u9f3b\u54bd\u764c\u6cbb\u7642\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3002\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u4e5f\u91dd\u5c0d\u5176\u9f3b\u54bd\u764c\u9069\u61c9\u75c7\u6388\u4e882\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u548c1\u9805\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u4e26\u65bc\u8fd1\u671f\u53d7\u7406\u4e86\u8a72\u85e5\u7269\u91cd\u65b0\u63d0\u4ea4\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u3002\u5982\u82e5\u6279\u51c6\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u4e5f\u5c07\u6210\u70ba\u7f8e\u570b\u9996\u500b\u4e14\u552f\u4e00\u7528\u65bc\u9f3b\u54bd\u764c\u6cbb\u7642\u7684\u816b\u7624\u514d\u75ab\u85e5\u7269\u3002<\/p>\n\n\n\n\n\n<p><strong>\u95dc\u65bc\u9f3b\u54bd\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u7a2e\u539f\u767c\u65bc\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u60e1\u6027\u816b\u7624\uff0c\u662f\u5e38\u898b\u7684\u982d\u9838\u90e8\u816b\u7624\u4e4b\u4e00\u3002\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u7d71\u8a08\uff0c2020\u5e74\u5168\u7403\u9f3b\u54bd\u764c\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e13\u842c<a href=\"#_ftn1\" id=\"_ftnref1\">[1]<\/a>\u3002\u7531\u65bc\u539f\u767c\u816b\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u63a1\u7528\u624b\u8853\u6cbb\u7642\uff0c\u5c40\u90e8\u75be\u75c5\u60a3\u8005\u4e3b\u8981\u63a1\u7528\u5316\u7642\u53ca\u653e\u7642\u6cbb\u7642\u3002\u5728\u7f8e\u570b\u548c\u6b50\u6d32\uff0c\u5c1a\u7121\u514d\u75ab\u7642\u6cd5\u7372\u6279\u7528\u65bc\u6cbb\u7642\u9f3b\u54bd\u764c\u3002<\/p>\n\n\n\n<ul class=\"has-small-font-size wp-block-list\">\n<li><a href=\"https:\/\/dianhuaminglu.com\/wp-admin\/post-new.php?lang=zh-hant#_ftnref1\">[1]<\/a> https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09<\/strong><\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u4f5c\u70ba\u6211\u570b\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u500b\u570b\u7522\u4ee5PD-1\u70ba\u9776\u9ede\u7684\u55ae\u6297\u85e5\u7269\uff0c\u7372\u5f97\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\u5c08\u6848\u652f\u6301\uff0c\u4e26\u69ae\u81ba\u570b\u5bb6\u5c08\u5229\u9818\u57df\u6700\u9ad8\u734e\u9805\u201c\u4e2d\u570b\u5c08\u5229\u91d1\u734e\u201d\u3002<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u81f3\u4eca\u5df2\u5728\u5168\u7403\uff08\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6771\u5357\u4e9e\u53ca\u6b50\u6d32\u7b49\u5730\uff09\u958b\u5c55\u4e86\u8986\u84cb\u8d85\u904e15\u500b\u9069\u61c9\u75c7\u768430\u591a\u9805\u7531\u516c\u53f8\u767c\u8d77\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u6b63\u5728\u9032\u884c\u6216\u5df2\u5b8c\u6210\u7684\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u5728\u591a\u500b\u7624\u7a2e\u7bc4\u570d\u5167\u8a55\u4f30\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u5b89\u5168\u6027\u53ca\u7642\u6548\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9f3b\u54bd\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u814e\u764c\u53ca\u76ae\u819a\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u62795\u9805\u9069\u61c9\u75c7\uff1a\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7642\uff082018\u5e7412\u6708\uff09\uff1b\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7642\uff082021\u5e742\u6708\uff09\uff1b\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u5305\u62ec\u65b0\u8f14\u52a9\u6216\u8f14\u52a9\u5316\u764212\u500b\u6708\u5167\u9032\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7642\uff082021\u5e744\u6708\uff09\uff1b\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u5c40\u90e8\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082021\u5e7411\u6708\uff09\uff1b\u806f\u5408\u7d2b\u6749\u9187\u548c\u9806\u9251\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u5fa9\u767c\u6216\u9060\u8655\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082022\u5e745\u6708\uff09\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u9996\u6b21\u901a\u904e\u570b\u5bb6\u91ab\u4fdd\u8ac7\u5224\uff0c\u76ee\u524d\u5df2\u67093\u9805\u9069\u61c9\u75c7\u7d0d\u5165\u300a2021\u5e74\u85e5\u54c1\u76ee\u9304\u300b\uff0c\u662f\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u4e2d\u552f\u4e00\u7528\u65bc\u6cbb\u7642\u9ed1\u8272\u7d20\u7624\u548c\u9f3b\u54bd\u764c\u7684\u6297PD-1\u55ae\u6297\u85e5\u7269\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u7121EGFR\u6216ALK\u7a81\u8b8a\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u76ee\u524d\u6b63\u5728\u63a5\u53d7\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u5be9\u8a55\u3002<\/p>\n\n\n\n<p>\u5728\u570b\u969b\u5316\u4f48\u5c40\u65b9\u9762\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u3001\u9f3b\u54bd\u764c\u3001\u8edf\u7d44\u7e54\u8089\u7624\u3001\u98df\u7ba1\u764c\u3001\u5c0f\u7d30\u80de\u80ba\u764c\u9818\u57df\u7372\u5f97FDA\u6388\u4e882\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u30011\u9805\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\u30011\u9805\u512a\u5148\u5be9\u8a55\u8a8d\u5b9a\u548c5\u9805\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u4e26\u5728\u9f3b\u54bd\u764c\u9818\u57df\u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6388\u4e88\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u30022022\u5e747\u6708\uff0cFDA\u53d7\u7406\u4e86\u91cd\u65b0\u63d0\u4ea4\u7684\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5409\u897f\u4ed6\u6ff1\/\u9806\u9251\u4f5c\u70ba\u665a\u671f\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\u548c\u55ae\u85e5\u7528\u4e8e\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u542b\u9251\u6cbb\u7642\u5f8c\u7684\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\uff0c\u8655\u65b9\u85e5\u7528\u6236\u4ed8\u8cbb\u6cd5\u6848\uff08PDUFA\uff09\u7684\u76ee\u6a19\u5be9\u8a55\u65e5\u671f\u5b9a\u70ba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