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\u5317\u4eac\u6642\u95932023\u5e746\u670828\u65e5\uff0c\u541b\u5be6\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u4f48\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u65bc\u8fd1\u65e5\u540c\u610f\u516c\u53f8\u958b\u5c55\u6297BTLA\u55ae\u6297tifcemalimab\uff08\u7522\u54c1\u4ee3\u865f\uff1aTAB004\/JS004\uff09\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u4f5c\u70ba\u5c40\u9650\u671f\u5c0f\u7d30\u80de\u80ba\u764c\uff08LS-SCLC\uff09\u653e\u5316\u7642\u5f8c\u672a\u9032\u5c55\u60a3\u8005\u7684\u978f\u56fa\u6cbb\u7642\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n

\u80ba\u764c\u662f\u76ee\u524d\u6211\u570b\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u6392\u540d\u9996\u4f4d\u7684\u60e1\u6027\u816b\u76241<\/sup>\uff0c\u6309\u7d30\u80de\u985e\u578b\u5927\u81f4\u5206\u70ba\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u3002\u5176\u4e2d\uff0cSCLC\u662f\u80ba\u764c\u4e2d\u4fb5\u8972\u6027\u6700\u5f37\u7684\u4e9e\u578b2<\/sup>\uff0c\u7d04\u5360\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u768415%-20%3<\/sup>\uff0c\u5177\u6709\u9032\u5c55\u8fc5\u901f\u3001\u65e9\u671f\u8f49\u79fb\u3001\u9810\u5f8c\u5dee\u7b49\u7279\u9ede4<\/sup>\u3002SCLC\u5206\u70ba\u5c40\u9650\u671f\uff08LS-SCLC\uff09\u548c\u5ee3\u6cdb\u671f\uff08ES-SCLC\uff09\uff0c\u5176\u4e2d\uff0cLS-SCLC\u7d04\u5360\u4e09\u5206\u4e4b\u4e005<\/sup>\u3002\u5c0d\u65bc\u7121\u6cd5\u624b\u8853\u6216\u62d2\u7d55\u624b\u8853\u7684LS-SCLC\u60a3\u8005\uff0c\u540c\u6b65\u653e\u5316\u7642\uff08CRT\uff09\u70ba\u6a19\u6e96\u6cbb\u7642\uff08SOC\uff09\u3002\u4f46\u662f\u9019\u985e\u60a3\u8005\u5373\u4fbf\u63a5\u53d7\u6a19\u6e96\u540c\u6b65\u653e\u5316\u7642\uff0c\u9810\u5f8c\u4ecd\u8f03\u5dee\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7d04\u70ba13.5\u500b\u6708\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u572816-24\u500b\u6708\uff0c5\u5e74\u751f\u5b58\u7387\u50c515%-26%6<\/sup>\uff0c<\/sup>7<\/sup>\u3002LS-SCLC\u7684\u6cbb\u7642\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u6cbb\u7642\u9700\u6c42\uff0c\u81e8\u5e8a\u4e9f\u9700\u63a2\u7d22\u7642\u6548\u66f4\u512a\u3001\u8010\u53d7\u6027\u826f\u597d\u7684\u65b9\u6848\u3002<\/p>\n\n\n\n

\u541b\u5be6\u751f\u7269\u8a08\u756b\u65bc\u8fd1\u671f\u555f\u52d5\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30tifcemalimab\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u7279\u745e\u666e\u5229\u55ae\u6297\u55ae\u85e5\u53ca\u5c0d\u6bd4\u5b89\u6170\u5291\u7528\u65bcCRT\u5f8c\u672a\u9032\u5c55LS-SCLC\u60a3\u8005\u7684\u978f\u56fa\u6cbb\u7642\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u70baBTLA\u9776\u9ede\u85e5\u7269\u9996\u500b\u78ba\u8b49\u6027\u7814\u7a76\uff0c\u5c07\u7531\u5c71\u6771\u7b2c\u4e00\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u9662\u9577\u4e8e\u91d1\u660e\u9662\u58eb\u64d4\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u8a08\u756b\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u7b49\u5730\u5165\u7d44756\u4f8b\u60a3\u8005\u3002<\/p>\n\n\n\n

\u541b\u5be6\u751f\u7269\u5168\u7403\u7814\u767c\u7e3d\u88c1\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u8fd1\u5e74\u4f86\uff0c\u816b\u7624\u514d\u75ab\uff08I-O\uff09\u6cbb\u7642\u767c\u5c55\u8fc5\u901f\uff0c\u5c24\u5176\u5728\u80ba\u764c\u9818\u57df\u5df2\u6210\u70ba\u665a\u671fNSCLC\u7684\u4e00\u7dda\u6cbb\u7642SOC\u3002\u800c\u5c0d\u65bc\u4fb5\u8972\u6027\u66f4\u5f37\u7684SCLC\uff0c\u514d\u75ab\u6cbb\u7642\u7684\u7814\u7a76\u9032\u5c55\u8f03\u70ba\u7de9\u6162\uff0c\u5168\u7403\u7bc4\u570d\u5167\u5c1a\u7121\u4efb\u4f55\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u7372\u6279\u7528\u65bcLS-SCLC\u3002Tifcemalimab\u4f5c\u70ba\u541b\u5be6\u751f\u7269\u9996\u6b3e\u81ea\u4e3b\u7814\u767c\u7684\u2018\u5168\u7403\u65b0\u2019\uff08first-in-class\uff09\u7522\u54c1\uff0c\u6709\u671b\u8207\u6211\u5011I-O\u7ba1\u7dda\u4e0a\u7684\u57fa\u77f3\u985e\u85e5\u7269\u7279\u745e\u666e\u5229\u55ae\u6297\u5f37\u5f37\u806f\u5408\uff0c\u63d0\u5347\u60a3\u8005\u5c0d\u514d\u75ab\u6cbb\u7642\u7684\u53cd\u61c9\uff0c\u64f4\u5927\u53ef\u80fd\u53d7\u76ca\u4eba\u7fa4\u7684\u7bc4\u570d\uff0c\u70baLS-SCLC\u4eba\u7fa4\u7684\u6cbb\u7642\u683c\u5c40\u5e36\u4f86\u65b0\u7a81\u7834\uff01\u201d<\/p>\n\n\n\n

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\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 Feb 4.<\/h5>\n\n\n\n
2.\u5f35\u723d\u7b49.\u5c0f\u7d30\u80de\u80ba\u764c\u500b\u9ad4\u5316\u6cbb\u7642\u9032\u5c55[J].\u4e2d\u570b\u816b\u7624\u81e8\u5e8a,2017,44(12):571-576.<\/h5>\n\n\n\n
3.Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.<\/h5>\n\n\n\n
4.Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.<\/h5>\n\n\n\n
5.Thatcher N, et al. Management of small-cell lung cancer. Ann Oncol. 2005;16 Suppl 2:ii235-9.<\/h5>\n\n\n\n
6.Faivre-Finn C, et al. Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial. Lancet Oncol. 2017 Aug;18(8):1116-1125.<\/h5>\n\n\n\n
7.Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.<\/h5>\n\n\n\n

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1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

\u95dc\u65bc<\/strong>tifcemalimab<\/strong>\uff08<\/strong>TAB004\/JS004<\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n

Tifcemalimab\uff08TAB004\/JS004\uff09\u662f\u541b\u5be6\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5168\u7403\u9996\u500b\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\uff08first-in-human\uff09\u7684\u6297\u816b\u7624\u91cd\u7d44\u4eba\u6e90\u5316\u6297BTLA\uff08B\u548cT\u6dcb\u5df4\u7d30\u80de\u8870\u6e1b\u56e0\u6578\uff09\u55ae\u514b\u9686\u6297\u9ad4\u3002\u76ee\u524d\uff0ctifcemalimab\u5df2\u7372\u51c6\u9032\u5165III\u671f\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\uff0c\u53e6\u6709\u591a\u9805\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u7684Ib\/II\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u540c\u6b65\u958b\u5c55\u4e2d\uff0c\u8986\u84cb\u591a\u500b\u7624\u7a2e\u3002<\/p>\n\n\n\n

Tifcemalimab\u6240\u91dd\u5c0d\u7684BTLA\u9776\u9ede\u65bc2003\u5e74\u767c\u73fe\uff0c\u70baCD28\u53d7\u9ad4\u5bb6\u65cf\u6210\u54e11<\/sup>\u3002\u5b83\u5177\u6709\u55ae\u500bIgSF V\u7d30\u80de\u5916\u57df\uff0c\u5176\u5e8f\u5217\u8207\u5176\u4ed6CD28\u5bb6\u65cf\u5206\u5b50\uff08\u4f8b\u5982PD-1\u548cCTLA-4\uff09\u5177\u6709\u76f8\u4f3c\u6027\u3002<\/p>\n\n\n\n

BTLA\u5728T\u548cB\u6dcb\u5df4\u7d30\u80de\u4ee5\u53ca\u6a39\u7a81\u72c0\u7d30\u80de\u4e9e\u7fa4\u4e0a\u8868\u9054\u3002BTLA\u8207\u5176\u914d\u9ad4HVEM\uff08Herpes virus entry mediator\uff0c\u76b0\u75b9\u75c5\u6bd2\u4fb5\u5165\u4ecb\u8cea\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u65bc2005\u5e74\u88ab\u767c\u73fe\uff0cHVEM\u662f\u5728\u9020\u8840\u7cfb\u7d71\u4e2d\u5ee3\u6cdb\u8868\u9054\u7684TNF\u53d7\u9ad4\uff0c\u88ab\u78ba\u5b9a\u70baBTLA\u7684\u914d\u9ad42<\/sup>\u3002<\/p>\n\n\n\n

BTLA\u662f\u4e00\u7a2e\u514d\u75ab\u7403\u86cb\u767d\u76f8\u95dc\u6027\u819c\u86cb\u767d\uff0c\u5176\u86cb\u767d\u7d50\u69cb\u985e\u4f3c\u65bc\u8de8\u819c\u53d7\u9ad4CTLA-4\u548cPD-1\u3002\u5728\u6b63\u5e38\u751f\u7406\u60c5\u6cc1\u4e0b\uff0cBTLA\u8207\u5176\u914d\u9ad4HVEM\u7d50\u5408\u5f8c\uff0c\u53ef\u4ee5\u6291\u5236\u6dcb\u5df4\u7d30\u80de\u7684\u904e\u5ea6\u6d3b\u5316\uff0c\u9632\u6b62\u514d\u75ab\u7cfb\u7d71\u5c0d\u81ea\u8eab\u7684\u640d\u50b72<\/sup>\u3002 Tifcemalimab\u901a\u904e\u7d50\u5408BTLA\uff0c\u963b\u65b7HVEM-BTLA\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5f9e\u800c\u963b\u65b7BTLA\u4ecb\u5c0e\u7684\u6291\u5236\u6027\u4fe1\u865f\u901a\u8def\uff0c\u6700\u7d42\u9054\u5230\u555f\u52d5\u816b\u7624\u7279\u7570\u6dcb\u5df4\u7d30\u80de\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. Watanabe, N., Gavrieli, M., Sedy, J.R., Yang,J., Fallarino, F., Loftin, S.K., Hurchla, M.A., Zimmerman, N., Sim, J., Zang, X., et al. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4, 670-679.<\/h5>\n\n\n\n
2. Sedy, J.R., Gavrieli, M., Potter, K.G., Hurchla, M.A., Lindsley, R.C., Hildner, K., Scheu, S., Pfeffer, K., Ware, C.F., Murphy, T.L., et al. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 6, 90-98.<\/h5>\n\n\n\n

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\u95dc\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<\/strong>\u00ae<\/sup><\/strong>\uff09<\/strong><\/strong><\/p>\n\n\n\n

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