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\u4f5c\u70ba\u570b\u5167\u9996\u500b\u9054\u6210\u967d\u6027\u7d50\u679c\u7684PD-(L)1\u6291\u5236\u5291\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0cMELATORCH\u7814\u7a76\uff08NCT03430297\uff09\u65e8\u5728\u6bd4\u8f03\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u9054\u5361\u5df4\u55ea\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6297\u816b\u7624\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u4e8e\u9054\u5361\u5df4\u55ea\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u53ef\u986f\u8457\u5ef6\u9577\u60a3\u8005\u7684PFS\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u5b89\u5168\u6027\u8cc7\u6599\u8207\u65e2\u5f80\u7814\u7a76\u76f8\u4f3c\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u672c\u7814\u7a76\u7684\u8a73\u7d30\u8cc7\u6599\u5c07\u5728\u5f8c\u7e8c\u7684\u570b\u969b\u5b78\u8853\u5927\u6703\u4e0a\u516c\u4f48\u3002<\/p>\n\n\n\n

MELATORCH\u7814\u7a76\u7684\u727d\u982d\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u90ed\u8ecd\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u6211\u5011\u901a\u904e\u2161\u671f\u7814\u7a76POLARIS-01\u8b49\u5be6\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u826f\u597d\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u800c\u672c\u6b21MELATORCH\u7814\u7a76\u7684\u6210\u529f\u5247\u6709\u671b\u9032\u4e00\u6b65\u5c07\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u7372\u76ca\u4eba\u7fa4\u7bc4\u570d\u64f4\u5c55\u81f3\u4e00\u7dda\u60a3\u8005\u3002\u5c0d\u6bd4\u50b3\u7d71\u5316\u7642\u85e5\u7269\uff0c\u63a5\u53d7\u7279\u745e\u666e\u5229\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u7684\u60a3\u8005\u64c1\u6709\u66f4\u512a\u7684PFS\uff0c\u4e26\u4e14\u5c0d\u65bc\u4e0d\u540c\u4e9e\u578b\u7684\u60a3\u8005\u5747\u53ef\u5be6\u73fe\u7372\u76ca\uff0c\u8207POLARIS-01\u7814\u7a76\u7d50\u679c\u4e00\u81f4\u3002\u671f\u5f85\u66f4\u591a\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u80fd\u5920\u53d7\u76ca\u4e8e\u6211\u5011\u7684\u9ad8\u54c1\u8cea\u4e2d\u570b\u5275\u65b0\u85e5\u7269\u3002\u201d<\/p>\n\n\n\n

\u541b\u5be6\u751f\u7269\u5168\u7403\u7814\u767c\u7e3d\u88c1\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u5f97\u76ca\u65bc\u6211\u570b\u5c0d\u65b0\u85e5\u7684\u52a0\u901f\u5be9\u8a55\u5be9\u6279\u653f\u7b56\uff0c2018\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u57fa\u65bc\u2161\u671f\u81e8\u5e8a\u7814\u7a76\u7372\u5f97\u9644\u689d\u4ef6\u6279\u51c6\u7528\u65bc\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642\uff0c\u586b\u88dc\u4e86\u570b\u7522\u6297PD-1\u55ae\u6297\u7684\u7a7a\u767d\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u4e2d\u570b\u816b\u7624\u60a3\u8005\u80fd\u5920\u7372\u5f97\u53ef\u53ca\u3001\u53ef\u8ca0\u64d4\u7684\u514d\u75ab\u6cbb\u7642\u30025\u5e74\u5f8c\uff0c\u6211\u5011\u5728\u9ed1\u8272\u7d20\u7624\u6cbb\u7642\u9818\u57df\u7e7c\u5f80\u958b\u4f86\uff0c\u901a\u904e\u2162\u671f\u78ba\u8b49\u6027\u7814\u7a76\u518d\u6b21\u8b49\u660e\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u7684\u5f37\u5927\u5be6\u529b\u3002\u6211\u5011\u5c07\u8207\u76e3\u7ba1\u6a5f\u69cb\u9032\u884c\u5bc6\u5207\u6e9d\u901a\uff0c\u4ee5\u671f\u5118\u65e9\u5be6\u73fe\u65b0\u9069\u61c9\u75c7\u7684\u8a3b\u518a\u548c\u843d\u5730\u61c9\u7528\u3002\u201c<\/p>\n\n\n\n

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\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249.<\/h5>\n\n\n\n
2. Wu Y, Wang Y, Wang L, Yin P, Lin Y, Zhou M. Burden of melanoma in China, 1990-2017: Findings from the 2017 global burden of disease study. Int J Cancer. 2020 Aug 1;147(3):692-701.<\/h5>\n\n\n\n
3. \u4e2d\u83ef\u4eba\u6c11\u5171\u548c\u570b\u570b\u5bb6\u885b\u751f\u5065\u5eb7\u59d4\u54e1\u6703\u9ed1\u8272\u7d20\u7624\u8a3a\u7642\u6307\u5357\uff082022\u5e74\u7248\uff09<\/h5>\n\n\n\n
4. \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u9ed1\u8272\u7d20\u7624\u8a3a\u7642\u6307\u5357\uff082022\u5e74\u7248\uff09<\/h5>\n\n\n\n

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1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/em><\/h6>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

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\u95dc\u65bcMELATORCH\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

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