{"id":2563,"date":"2023-11-23T08:00:00","date_gmt":"2023-11-23T00:00:00","guid":{"rendered":"https:\/\/dianhuaminglu.com\/?p=2563"},"modified":"2024-01-03T18:33:38","modified_gmt":"2024-01-03T10:33:38","slug":"%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e6%96%b0%e5%86%a0%e5%8f%a3%e6%9c%8d%e8%8d%af%e6%b0%91%e5%be%97%e7%bb%b4%e7%ac%ac2%e9%a1%b9%e4%b8%89%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e8%8d%a3","status":"publish","type":"post","link":"https:\/\/dianhuaminglu.com\/zh-hant\/%e5%90%9b%e5%ae%9e%e7%94%9f%e7%89%a9%e6%96%b0%e5%86%a0%e5%8f%a3%e6%9c%8d%e8%8d%af%e6%b0%91%e5%be%97%e7%bb%b4%e7%ac%ac2%e9%a1%b9%e4%b8%89%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e8%8d%a3\/","title":{"rendered":"\u541b\u5be6\u751f\u7269\u65b0\u51a0\u53e3\u670d\u85e5\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u7b2c2\u9805\u4e09\u671f\u7814\u7a76\u7d50\u679c\u69ae\u767b\u300a\u67f3\u8449\u5200-\u611f\u67d3\u75c5\u5b78\u300b"},"content":{"rendered":"\n<p>\u5317\u4eac\u6642\u95932023\u5e7411\u670823\u65e5\uff0c\u570b\u969b\u611f\u67d3\u75c5\u5b78\u671f\u520a\u6392\u540d\u7b2c\u4e00\u7684\u300a\u67f3\u8449\u5200-\u611f\u67d3\u75c5\u5b78\u300b\uff08<em>The Lancet Infectious Diseases<\/em>\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a56.3\uff09\u767c\u4f48\u4e86\u570b\u7522\u65b0\u51a0\u53e3\u670d\u85e5\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\uff08\u6c2b\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97cb\u7247\uff0c\u7522\u54c1\u4ee3\u865f\uff1aVV116\/JT001\uff09\u7684\u4e00\u9805\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u7d50\u679c\u3002\u64da\u77ad\u89e3\uff0c\u9019\u662f\u9996\u500b\u5728\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u767c\u8868\u7684\u570b\u7522\u65b0\u51a0\u53e3\u670d\u85e5\u2162\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\uff0c\u4e5f\u662f\u7e7c2022\u5e74\u5e95\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5be6\u73fe\u9996\u500b\u4e2d\u570b\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u51a0\u5275\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u9996\u767b\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08<em>NEJM<\/em>\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a158.5\uff09\u4e4b\u5f8c\uff0c\u7b2c\u4e8c\u9805\u7372\u5f97\u570b\u969b\u5b78\u8853\u754c\u8a8d\u53ef\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u57fa\u65bc\u8a72\u7814\u7a76\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5df2\u65bc\u4eca\u5e741\u6708\u5728\u4e2d\u570b\u7372\u6279\u7528\u65bc\u6cbb\u7642\u8f15\u3001\u4e2d\u5ea6COVID-19\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"1152\" height=\"492\" src=\"https:\/\/dianhuaminglu.com\/wp-content\/uploads\/2023\/12\/Lancet-Infec-Dis.jpg\" alt=\"\" class=\"wp-image-2555\"\/><figcaption class=\"wp-element-caption\">\u6765\u6e90\uff1a<em>The Lancet Infectious Diseases<\/em>\u5b98\u7db2<\/figcaption><\/figure>\n\n\n\n<p>\u672c\u6b21\u767c\u8868\u57fa\u65bc\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT05582629\uff09\uff0c\u7531\u6d59\u6c5f\u5927\u5b78\u50b3\u67d3\u75c5\u8a3a\u6cbb\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e3b\u4efb\u674e\u862d\u5a1f\u9662\u58eb\u727d\u982d\uff0c\u5728\u5168\u570b31\u5bb6\u4e2d\u5fc3\u958b\u5c55\u3002\u674e\u862d\u5a1f\u9662\u58eb\u70ba\u8ad6\u6587\u7684\u901a\u8a0a\u4f5c\u8005\uff0c\u4e0a\u6d77\u5e02\u516c\u5171\u885b\u751f\u81e8\u5e8a\u4e2d\u5fc3\u8303\u5c0f\u7d05\u6559\u6388\u548c\u6de9\u96f2\u6559\u6388\uff0c\u6d59\u6c5f\u6a39\u4eba\u5927\u5b78\u6a39\u862d\u570b\u969b\u91ab\u5b78\u9662\u9644\u5c6c\u6a39\u862d\uff08\u676d\u5dde\uff09\u91ab\u9662\u6234\u971e\u7d05\u6559\u6388\u3001\u5433\u9e97\u82b1\u6559\u6388\u548c\u6e6f\u9748\u73b2\u6559\u6388\u4f5c\u70ba\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n\n\n\n<p>\u8a72\u7814\u7a76\u5728\u671f\u4e2d\u5206\u6790\u968e\u6bb5\u5373\u5df2\u7372\u5f97\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u7d50\u679c\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u6cbb\u7642\u8f15\u3001\u4e2d\u5ea6\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u6210\u4eba\u60a3\u8005\uff08\u226518\u6b72\uff09\u53ef\u986f\u8457\u7e2e\u77ed\u54b3\u55fd\u3001\u6d41\u6d95\u3001\u767c\u71b1\u3001\u8179\u7009\u7b4911\u9805\u81e8\u5e8a\u75c7\u72c0\u7684\u6d88\u5931\u6642\u9593\uff0c\u4e2d\u4f4d\u6642\u9593\u6bd4\u5b89\u6170\u5291\u7d44\u7e2e\u77ed2\u5929\uff08HR=1.21\uff0cP=0.0023)\u3002\u6700\u7d42\u5206\u6790\u7d50\u679c\u8207\u671f\u4e2d\u5206\u6790\u4e00\u81f4\uff0c\u75c7\u72c0\u6d88\u5931\u4e2d\u4f4d\u6642\u9593\u6bd4\u5b89\u6170\u5291\u7d44\u7e2e\u77ed2\u5929\uff08HR=1.17\uff0cP=0.0009)\uff0c\u70ba\u570b\u5167\u5916\u65b0\u51a0\u53e3\u670d\u85e5\u5df2\u5831\u5c0e\u8cc7\u6599\u4e2d\u8868\u73fe\u6700\u512a\uff0c\u9032\u4e00\u6b65\u8b49\u660e\u4e86\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u7684\u7642\u6548\u7372\u76ca\u300260\u6b72\u4ee5\u4e0a\u8001\u5e74\u60a3\u8005\u7684\u4e9e\u7d44\u5206\u6790\u8cc7\u6599\u8207\u6574\u9ad4\u4eba\u7fa4\u4e00\u81f4\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"1252\" height=\"600\" src=\"https:\/\/dianhuaminglu.com\/wp-content\/uploads\/2024\/01\/\u81f3\u6301\u7eed2\u5929\u75c7\u72b6\u8bc4\u5206\u4e3a0.jpg\" alt=\"\" class=\"wp-image-2577\"\/><figcaption class=\"wp-element-caption\">\u81f3\u6301\u7e8c2\u5929\u81e8\u5e8a\u75c7\u72c0\u6d88\u5931\u6642\u9593<\/figcaption><\/figure>\n\n\n\n<p>\u6b64\u5916\uff0c\u622a\u81f3\u7d66\u85e5\u7b2c5\u5929\uff0c\u63a5\u53d7\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u6cbb\u7642\u7684\u60a3\u8005\u75c5\u6bd2\u8f49\u9670\u6bd4\u4f8b\u660e\u986f\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0841.6% vs 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\u3011<\/h5>\n\n\n\n<h5>1. Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study. The Lancet Infectious Diseases. DOI:10.1016\/S1473-3099(23)00577-7.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<h6><em>1. <em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n<h6><em>2. <em>\u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><strong><strong><strong><strong>\u95dc\u65bc\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\uff08\u6c2b\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97cb\u7247\uff0cVV116\/JT001\uff09<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p>VV116\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u985e\u85e5\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u8907\u88fd\u3002\u81e8\u5e8a\u524d\u85e5\u6548\u5b78\u7814\u7a76\u986f\u793a\uff0cVV116\u5728\u9ad4\u5916\u5c0d\u5305\u62ec\u5967\u5bc6\u514b\u620e\u5728\u5167\u7684\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u7a81\u8b8a\u682a\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff1b\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u4f4e\u5291\u91cf\u7684VV116\u5c31\u53ef\u5c07\u80ba\u90e8\u75c5\u6bd2\u6ef4\u5ea6\u964d\u4f4e\u81f3\u6aa2\u6e2c\u9650\u4ee5\u4e0b\uff0c\u53ef\u986f\u8457\u6539\u5584\u80ba\u7d44\u7e54\u75c5\u7406\u8b8a\u5316\uff0c\u8868\u73fe\u51fa\u8f03\u5f37\u7684\u6297\u75c5\u6bd2\u529f\u6548\u3002\u81e8\u5e8a\u524d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7b49\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cVV116\u5177\u6709\u5f88\u9ad8\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u53e3\u670d\u5438\u6536\u5f8c\uff0c\u8fc5\u901f\u4ee3\u8b1d\u70ba\u6bcd\u9ad4\u6838\u82f7\uff0c\u4e26\u5728\u9ad4\u5167\u7d44\u7e54\u5ee3\u6cdb\u5206\u4f48\u3002<\/p>\n\n\n\n<p>VV116\u7531\u4e2d\u570b\u79d1\u5b78\u9662\u4e0a\u6d77\u85e5\u7269\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u6b66\u6f22\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u65b0\u7586\u7406\u5316\u6280\u8853\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u4e2d\u4e9e\u85e5\u7269\u7814\u767c\u4e2d\u5fc3\/\u4e2d\u70cf\u91ab\u85e5\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e36\u4e00\u8def\u201d\u806f\u5408\u5be6\u9a57\u5ba4\uff09\u3001\u81e8\u6e2f\u5be6\u9a57\u5ba4\u3001\u8607\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff08\u65fa\u5c71\u65fa\u6c34\uff09\u548c\u541b\u5be6\u751f\u7269\u5171\u540c\u7814\u767c\u3002<\/p>\n\n\n\n<p>\u5728\u65b0\u51a0\u75ab\u60c5\u671f\u9593\uff0cVV116\u958b\u5c55\u4e86\u591a\u9805\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u3002 1\u9805\u5728\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u5c0d\u6bd4PAXLOVID\u7528\u65bc\u8f15\u4e2d\u5ea6COVID-19\u65e9\u671f\u6cbb\u7642\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08JT001-010\uff09\u7372\u5f97\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08<em>The New England Journal of Medicine<\/em>\uff09\u767c\u8868<sup>[1]<\/sup>\uff0c\u53e61\u9805\u5728\u4f34\u6216\u4e0d\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08JT001-015\uff09\u7372\u5f97\u570b\u969b\u9802\u5c16\u611f\u67d3\u75c5\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200-\u611f\u67d3\u75c5\u5b78\u300b\uff08<em>The Lancet Infectious Diseases<\/em>\uff09\u767c\u8868<sup>[2]<\/sup>\u3002<\/p>\n\n\n\n<p>2021\u5e7412\u6708\uff0cVV116\u5728\u70cf\u8332\u5225\u514b\u65af\u5766\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u3002<\/p>\n\n\n\n<p>2023\u5e741\u6708\uff0cVV116\u5728\u4e2d\u570b\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u8f15\u4e2d\u5ea6COVID-19\u7684\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<h5>\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n<h5>1. Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n\n<h5>2. Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study. The Lancet Infectious Diseases. DOI:10.1016\/S1473-3099(23)00577-7.<\/h5>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac\u65f6\u95f42023\u5e7411\u670823\u65e5\uff0c\u56fd\u9645\u611f\u67d3\u75c5\u5b66\u671f\u520a\u6392\u540d\u7b2c\u4e00\u7684\u300a\u67f3\u53f6\u5200-\u611f\u67d3\u75c5\u5b66\u300b\uff08The Lancet Infectious Diseases\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a56.3\uff09\u53d1\u5e03\u4e86\u56fd\u4ea7\u65b0\u51a0\u53e3\u670d\u836f\u6c11\u5f97\u7ef4\u00ae\uff08\u6c22\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97e6\u7247\uff0c\u4ea7\u54c1\u4ee3\u53f7\uff1aVV116\/JT001\uff09\u7684\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u6570\u636e\u3002<\/p>\n","protected":false},"author":3,"featured_media":2556,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[21],"tags":[],"yoast_head":"\n<title>\u541b\u5be6\u751f\u7269\u65b0\u51a0\u53e3\u670d\u85e5\u6c11\u5f97\u7dad\u00ae\u7b2c2\u9805\u4e09\u671f\u7814\u7a76\u7d50\u679c\u69ae\u767b\u300a\u67f3\u8449\u5200-\u611f\u67d3\u75c5\u5b78\u300b - \u541b\u5b9e\u751f\u7269<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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